HUMAN GLUTATHIONE S-TRANSFERASE A1-1 BINDING WITH NATURALLY OCCURRING LIGANDS: ASSESSMENT BY DOCKING SIMULATIONS
Glutathione S-transferases are phase-II enzymes associated with detoxification and resistance to drugs and xenobiotics. The majority of human tumors and human tumor cell lines express significant amounts of alpha class Glutathione S-Transferase A1-1. Present study aimed to examine hGSTA1-1 interaction with some naturally occurring ligands using docking simulations. Docking simulation using Glutath...
Calotropis gigantea, belonging to the family of Asclepiadaceae. The plant has the antimicrobial activity, antioxidant activity, analgesic activity, anti-pyretic activity, insecticidal activity, cytotoxicity activity, hepatoprotective activity, purgative properties and wound healing activity. The present paper is an attempt to provide a detailed botanical description, classification, phytochemical ...
ANTIOXIDANT ACTIVITY BY DPPH RADICAL SCAVENGING METHOD OF METHANOLIC EXTRACT OF N- BUTANOL FRACTRION OF TRIBULUS TERRESTRIS LINN. (FAMILY ZYGOPHYLLACEAE)
In this study antioxidant activity was performed by DPPH (1,1 diphenyl-2-picrylhydrazyl) radical scavenging method for Tribulus terrestris L. whole plant methanolic extraction fractionation with toluene and n-butanol in succession. The obtained fractions were concentrated under reduced pressure to yield corresponding antioxidant activity. The IC50 concentration for the standard, ascorbic acid and ...
COMPARATIVE STUDY OF THE EFFECTS OF DILTIAZEM VERSUS ALPHA TOCOPHEROL ON RETINAL DEGENATION IN RABBITS
Disturbance in retinal blood supply can have an effect on the supply of oxygen and the substrates which leads to retinal ischemia, the result is irreversible, ischemic and apoptotic cascades resulting in cell death. The present study was conducted to study the protective effects of diltiazem and vitamin E "alpha-tocopherol," against degenerative ischaemic retinal changes induced by Middle Cerebral...
CHEMICAL CONSTITUENTS AND TYROSINASE INHIBITORY ACTIVITY OF AQUEOUS FRACTION OF THE LEAVES OF MORUS ALBA LINN. FROM VIETNAM
The mulberry has been widely cultivated to feed silkworms. The leaves of mulberry have been used in traditional medicine as an analgesic, antitussive, cathartic, diuretic. In this study, we have isolated three compounds (LC1-3) by chromatographic methods from the mulberry leaves (Morus alba L.) collected in Thai Nguyen province, Vietnam. These compounds were identified as Kaempferol-3, 7-di-O-α-L...
Baccaurea ramiflora Lour., syn. Baccaurea sapida (Roxb.) Muell. Arg. known as Burmese grapes belongs to the family Euphorbiaceae and is native to Southeast Asia. The observance on Baccaurea ramiflora leads that this plant is utilized as an antichloristic and anodyne against rheumatoid arthritis, abscesses, cellulitis and treat injuries. This plant also has anti-diarrheal, analgesic, anti-inflammat...
Diabetes mellitus (DM), both type I and type II, is a common metabolic disorder worldwide. It is characterized by hyperglycemia, lipid, and protein metabolism abnormalities, and accompanied by several clinical complications including retinopathy, neuropathy, and nephropathy. Many traditional herbs have been used for the treatment of DM. In the present review, we showed a list of these herbs descri...
IN-VITRO ANTI-OXIDANT STUDIES OF MACERATED ETHANOLIC AND AQUEOUS EXTRACT OF HYLOCEREUS UNDATUS FRUITS
Hylocereus undatusis an important medicinal plant belonging to the family Cactaceae and widely distributed in tropical forest areas. Fruits are used for anti-bacterial, anti-oxidant, antipyretic, antidiabetic and hepato-protective activities of the plants are scientifically proved. The aim of the present study is to evaluate Hylocereus undatus pharmacologically for the anti-oxidant study. The stud...
Introduction: Picrorhiza kurroa is a well-known plant used in Ayurvedic medicines belonging to the family, Scrophul-ariaceae. This herb has been traditionally used in treating liver disorders, upper respiratory tract disorders, reduce fever, scorpion stings, and treat dyspepsia and chronic diarrhea. Experiment: The macroscopy, microscopy, powder microscopy, physiochemical screening was done on Pic...
Bauhinia Variegata Linn. is a widely used medicinal plant distributed in the tropical regions throughout the world. Its various part i.e. flowers, flower buds, stem, roots, stem bark, seeds, leaves have been used since ancient times for the treatment of a large range of diseases such as dysentery, diarrhoea, haemorrhoids, piles, oedema, laxative, anthelmintic, astringent, antileprotic, wound heali...