DETERMINATION OF ANTIOXIDANT ACTIVITY OF CROCUS SATIVUS IN ADJUVANT INDUCED ARTHRITIC MICEAbstract
Rheumatoid arthritis (RA) is a chronic systemic disease which results in pain, swelling, and stiffness in joints. It affects about 1% of the total world’s population. RA begins with an edematous thickening of the synovia which latter converts into inflammatory synovium called pannus which erodes the surrounding cartilage. Conventional therapy exists to overcome illness but prolonged uses of drugs cause various side effects. Several reports demonstrate herbal remedy for RA treatment. Saffron is the natural yellow spice derived from the flower of Crocus sativus, possess antioxidant, anti-inflammatory activities. Therefore, in this study role of saffron for its treatment has been explored in AIA mice. The effect of three doses of ethanolic extracts of Crocus sativus (Family: Iridaceae) on adjuvant-induced arthritic mice was examined and evaluated. FCA injection caused a significant increase in joint inflammation. A daily oral dose of Crocus sativus extract (CSE) for 47 days resulted in a significant decrease in Lipid peroxides level as compared to AIA mice, while on the other hand the significant increase in Catalase and Glutathione peroxidase activity was recorded. From the present study, it may be concluded that CSE is effective in scavenging the free radical and hence capable of reducing oxidative stress during disease.
K. Jaggi *, S. K. Thakur, B. Rathore, R. Chander, F. Mahdi and A. Mathur
Department of Biochemistry, Era’s Lucknow Medical College & Hospital, Sarfarazganj, Lucknow, Uttar Pradesh, India.
28 March 2014
17 April 2014
30 April 2014
01 May 2014