![SYNTHESIS OF SOME NEW ANTIMICROBIAL 5,6,7,8-TETRAHYDROPYRIMIDO [4,5-b] QUINOLONE DERIVATIVES](https://ijpjournal.com/wp-content/uploads/2014/07/img2.jpg)
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by persistent hyperglycemia arising from insulin resistance and progressive β-cell dysfunction. Adenosine monophosphate-activated protein kinase (AMPK), a heterotrimeric serine/threonine kinase and central cellular energy sensor, has emerged as an attractive pharmacological target because its activation enhances periphe...
Rheumatoid arthritis (RA) is a long-term systemic autoimmune disease marked by systemic problems, progressive joint deterioration, and persistent synovial inflammation. Environmental contaminants, asbestos and silica dust from the workplace, smoking, vitamin D insufficiency, and hormonal factors all contribute to oxidative stress and immunological activation, which in turn promotes autoimmunity an...
Adenium obesum, commonly known as Desert Rose, belongs to the family Apocynaceae and is widely distributed in Africa and tropical regions. Traditionally valued as an ornamental and medicinal plant, it possesses diverse pharmacological properties attributed to its rich phytochemical composition, including alkaloids, flavonoids, glycosides, terpenoids, tannins, and phenolic compounds. Various studie...
Aegle marmelos or bael fruit is an important source of traditional medicine and attracts much attention because of the different phytochemistry in its composition as well as many health benefits. This review focuses on phytochemicals in bael fruits and their potential effects on health management. Different bioactive compounds are present in the fruit including tannins, coumarins, alkaloids, flavo...
Bryophyllum pinnatum or Kalanchoe pinnata, commonly known as the air plant, life plant, or miracle leaf, belongs to the Crassulaceae family. Due to its strong nephroprotective (kidney-protecting) and anti-urolithiatic qualities, this prospective medicinal plant is widely used, especially for the treatment of kidney and gall bladder stones. A comprehensive review was conducted through an online stu...
The present study was to investigate the analgesic and anthelmintic activities of ethanolic flower extract of Microcos paniculata, a member of the Malvaceae family. The analgesic activity was evaluated for its peripheral pharmacological activity using acetic acid induced writhing method in swiss albino mice at the doses of 200 and 400 mg/kg body weight and displayed significant analgesic action in...
The present study undertook a systematic, comprehensive pharmacognostical, phytochemical, and pharmacological investigation of Moringa oleifera leaves. The investigation was designed to address identified research gaps pertaining to the standardization, phytochemical characterization, and biological activity evaluation of this pharmacologically significant plant. Pharmacognostical characterization...
Curcumin, the principal polyphenolic constituent of Curcuma longa (turmeric), possesses potent anti-inflammatory activity. Despite remarkable pharmacological potential, clinical translation of curcumin is severely restricted by its drawbacks. The present study aimed to develop, optimize, and evaluate curcumin-loaded chitosan nanoparticles using Box-Behnken Design (BBD), and to compare their in-vit...
Carbon dots (CDs) have emerged as an important class of carbon-based nanomaterials owing to their excellent photoluminescence, biocompatibility, low toxicity, aqueous dispersibility, and versatile surface chemistry. The present study focused on the synthesis and physicochemical characterization of nitrogen-doped carbon dots prepared through a simple hydrothermal method using citric acid monohydrat...
The present study was designed to develop, optimise, and comprehensively evaluate a polyherbal antimicrobial gel made up from Azadirachta indica, Curcuma longa, Curcuma longa, Aloe vera, and Centella asiatica. Dry powder extracts were subjected to preliminary phytochemical screening, quantitative estimation of total phenolic content (TPC) and total flavonoid content (TFC), and validated HPTL.C In ...
