Posted by admin on Sep 30, 2025 in |
Diabetic wounds represent one of the most challenging complications of diabetes mellitus, characterized by impaired tissue regeneration, prolonged inflammation, and high susceptibility to infection. Conventional therapies often fail to achieve satisfactory healing outcomes, necessitating the exploration of novel strategies. Probiotics, with their antimicrobial, immunomodulatory, and regenerative properties, have emerged as promising candidates for wound care. This study investigated the therapeutic potential of three commercially available probiotic strains Bacillus clausii (Enterogermina®), Lactobacillus sporogenes (Sporlac®), and Bifidobacterium longum (Florachamp®) incorporated into a PEG–glycerol-based gel formulation for topical application. The developed gels were characterized for physicochemical stability, spreadability, pH, and viscosity, alongside confirmation of probiotic viability. In vitro assays revealed variable antagonistic activity against Staphylococcus aureus and Pseudomonas aeruginosa. Using a streptozotocin–nicotinamide-induced diabetic excision wound model in Wistar rats, the probiotic gels demonstrated significantly enhanced wound contraction, accelerated closure, and histological evidence of collagen deposition and re-epithelialization compared to diabetic controls. By Day 21, probiotic-treated groups exhibited healing efficacy comparable to the standard treatment (Placentrex® gel), with formulations containing Lactobacillus sporogenes and...
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Posted by admin on Aug 31, 2025 in |
The present study focuses on the formulation and evaluation of a natural lip balm utilizing polyherbal ingredients. The formulation incorporates cocoa butter, coconut oil, castor oil, honey, aloe vera gel, beetroot extract, pomegranate extract, rose oil, and vitamin E oil to provide moisturizing, antioxidant, and healing benefits. A total of 80 millilitres of lip balm was prepared following a stepwise method: melting the base ingredients, followed by the addition of humectants and heat-sensitive herbal extracts at controlled temperatures to preserve their bioactive properties. The herbal extracts not only impart therapeutic effects but also act as naturalcolorants and fragrance enhancers. The developed lip balm aims to offer effective lip protection, hydration, and a soothing effect, with minimal use of synthetic additives. Evaluation parameters such as appearance, pH, spreadability, melting point, and stability were assessed to ensure the product’s efficacy and consumer acceptability. The study highlights the potential of natural and polyherbal formulations in developing safe, effective, and eco-friendly cosmetic...
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Posted by admin on Aug 31, 2025 in |
Bacterial infections remain a serious threat to ornamental fish aquaculture, especially goldfish (Carassius auratus), which are highly valued for their aesthetic and commercial importance. Among the major pathogens, Aeromonas hydrophila, Pseudomonas fluorescens, and Edwardsiella tarda cause diseases such as hemorrhagic septicemia, fin rot, and edwardsiellosis, often leading to severe economic losses. Conventional reliance on antibiotics like ampicillin and tetracycline, though effective, has led to antibiotic resistance, environmental concerns, and consumer preference for residue-free fish, driving the search for natural alternatives. This study investigated the antibacterial properties of neem (Azadirachta indica) and fenugreek (Trigonella foenum-graecum) extracts against common fish pathogens. Extracts were prepared using cold maceration in 70% ethanol and tested via the Kirby-Bauer disc diffusion method at concentrations of 100, 200, and 400 mg/mL. Neem extract showed strong, dose-dependent antibacterial activity against A. hydrophila, producing inhibition zones of 12.3–21.4 mm due to its bioactive compounds like azadirachtin, nimbin, and nimbidin. Fenugreek extract exhibited moderate inhibition (7.2–12.8 mm), while antibiotics produced larger zones (e.g., ampicillin 25.6 mm). In vivo evaluation...
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Posted by admin on Aug 31, 2025 in |
The present study focuses on identification of bioactive compounds from Methanolic extraction of Indigofera prostrate, by GC–MS analysis and also evaluated the efficacy of Indigofera prostrate for antioxidant activity. Phytochemical screening of the Methanolic extraction of Indigofera prostrate revealed the presence of flavonoids, phenolic compounds, triterpenoids, tannins, saponins, amino acids, proteins, Steroids, Gums and carbohydrates. Gas chromatography-mass spectrometry (GC-MS) analysis of the methanol extract of Indigofera prostrate was performed on a GC-MS equipment. The GC-MS analysis has shown the presence of different bio active compounds in the Methanolic extract of Indigofera prostrate. A total of 14 compounds were identified in methanolic extraction in that the main active compounds are Campesterol, Stigmasterol, γ-Sitosterol, Lupeol. From the results, it is evident that Indigofera prostrate contains various phytocomponents and is recommended as a plant of phytopharmaceutical...
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Posted by admin on Jun 30, 2025 in |
Chocolate is the most loving food among the people. It is the easiest form to chew and absorb for every individual. This research deals into the Innovative application of herbal chocolates, a delightful fusion of traditional enjoyment and holistic well-being. The blending of herbal ingredients with the luxurious texture of chocolate has given rise to a new category of confectionery that not only satisfies sweet cravings but also offers potential health advantages. The essential target of this study was to formulate and evaluate nutritious chocolate and nutritional supplement containing anti arthritis property. Chocolate is a range of products derived from cocoa (cocoa) mixed with fat and finely powered coconut sugar to produce a solid confectionery. Sesame is the herbal drug which has several medicinal properties, like anti arthritis property, antioxidant property, from the prevention of rheumatoid arthritis. Sesame was used to improve blood pressure and act as anti aging agent. Thus, we have to formulate the chocolate with aqueous extract of sesame. Chocolate is a sophisticated and infinitely adaptable...
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