Posted by admin on Dec 31, 2021 in |
Background: The most common disease of endocrine disorder is diabetes due to underlying causes and pathophysiologies. It is spreading swiftly worldwide and is expected to reach up to 4.4% in the world by 2030. There are numerous synthetic glucose-lowering drugs on the market, but they all have detrimental effects. As a result, this necessitates the search for an alternative anti-diabetic agent from a natural source, i.e., herbal remedies that have been used traditionally and have a safe profile. Aim of the study: The purpose of this study was to look into the anti-diabetic activity of C. cuspidatus methanolic leaves extract on the glycation of Bovine Serum Albumin by measuring fluorescence intensity at various concentrations (1 mg/ml, 2 mg/ml, 4 mg/ml, 6 mg/ml, 8 mg/ml, 10 mg/ml) using positive control 1mM of Aminoguanidine (1 mg/ml, 2 mg/ml, 4 mg/ml, 6 mg/ml, 8 mg/ml, 10 mg/ml). Methodology: Phytochemical screening of Chamaecostus cuspidatus for determination of Phytoconstituents. BSA- Glucose Assay for in-vitro Glycation- methodology (Brownlee et al., 2013). BSA (l0 mg/mL) was...
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Posted by admin on Dec 31, 2021 in |
Essential oils are largely employed for their therapeutic properties, being marketed extensively in pharmaceutical and cosmetic industry. Lavender oil is known for its excellent aroma. Therefore, it is extensively used in the cosmetic, perfumery, and flavour industries. The lavender oil is known to possess sedative, carminative, antidepressive, and anti-inflammatory properties. The aim of our study was to assess the purity and quality of lavender oils, available on the market from various commercial producers. Therefore, essential oil compositions of lavender oil were analyzed using gas chromatography-mass spectrometry (GC-MS). Chromatographic analyses were carried out on HP-5 MS column. The injector volume was 1 µl in split mode (40:1) and the carrier gas was helium at a flow rate of 0.8 ml/min. 33 essential chemical constituents were identified based on GC-MS in lavender oil supplied from an herbalist. The major components of the lavender oil were found linalyl acetate (37.82 %), linalool (33.07 %), eucalyptol (4.88 %), camphor (4.07 %), lavandulol acetate (1.53 %) and caryophyllene (1.43...
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Posted by admin on Nov 30, 2021 in |
Neurodegenerative movement disorder of the central nervous system (CNS) (Parkinson’s disease (PD)) is characterized by necrosis of dopaminergic neurons within the substan tianigra pars compacta are ain the midbrain. The PD cause is still unknown and seems to be multifactorial. Oxidative stress and mitochondrial impairment have been the main consequences, which offer prominent clues regarding the disease mechanisms. The effect of free radicals and oxidative stress on the cascade of events resulting in dopamine cell degeneration in PD has been demonstrated. In-built protective mechanisms, including enzymatic and non-enzymatic antioxidants within the CNS, effectively prevent neuronal cell loss because of free radicals. However, aging is associated with a decrease in the production of these antioxidants. Thus, antioxidant therapy alone or combined with available treatment methods offers an attractive method to treat or prevent neurodegeneration in PD. We summarized the recent discoveries of potential antioxidant agents to modulate free radical-mediated oxidative stress resulting in neurotoxicity in...
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Posted by admin on Oct 31, 2021 in |
The present work deals with pharmacological studies of the formulated tablet of Bombax ceiba Linn. root extract. An aphrodisiac activity by mating behaviour test model was investigated. The dissolved tablet slurry (400 mg/kg body wt. /day) was administered orally by gavages for 28 days. Mount latency (ML), intromission latency (IL), ejaculation latency (EL), mounting frequency (MF), intromission frequency (IF), ejaculation frequency (EF) and post-ejaculatory interval (PEI) are the parameters observed before and during the sexual behaviour study at day 0, 7, 14, 21 and 28. The formulated tablet significantly reduced ML, IL, EL and PEI (p<0.05). The formulated tablet significantly increased MF, IF and EF (p<0.05). These effects were observed in sexually active and inactive male mice. Bombax ceiba roots extract tablets (400 mg/kg body wt.) have comparative aphrodisiac activity in inactive...
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Posted by admin on Sep 30, 2021 in |
Herbal medicines have attracted the researcher’s attention nowadays AS scientific evidence is regularly coming on their safety and efficacy. The present study of Hobibatul Katan Murakkab (Granules of Flaxseeds Compound) was undertaken to standardize the classical clinically proved effective Unani compound formulation “Hobibatul Katan Murakkab (Granules of Flaxseeds Compound)”. The study revealed the presence of Alkaloids, Glycosides, Tannins, and Fats. The presence of phytochemical compounds shows the potential of the compound in the field of medicine, as has been claimed by the Unani Physicians centuries ago. Preliminary phytochemical screening of the compound formulation has been done on a small scale. The formulation may be standardized on a large scale with full parameters of compound formulations of herbal...
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