Posted by admin on Apr 30, 2026 in |
Herbal candy is an innovative solid oral dosage form designed for localized soothing relief in the oral cavity and throat. Three formulations (F1, F2, F3) were prepared using fennel (Foeniculum vulgare), ginger (Zingiber officinale), and lemon (Citrus limon) in a sucrose base by the heating and molding method with varying herbal concentrations. All formulations were evaluated for organoleptic properties, weight variation, hardness, dissolution time, surface pH, moisture content, ash value, melting point, and stability over four weeks. Formulation F2 demonstrated the optimum profile: smooth texture, green color, aromatic odor, hardness 6.8 kg/cm², dissolution time 13 min, surface pH 4.5, weight 5.4±0.04 g, and complete stability at 25°C and 35°C for four weeks. The study confirms herbal candy as a safe, patient-friendly dosage form for mild throat discomfort, combining traditional herbal knowledge with modern pharmaceutical formulation...
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Posted by admin on Apr 30, 2026 in |
The present study evaluated the antiarthritic activity of the ethanol extract of Tephrosia purpurea (EETP) in experimental animal models. Acute oral toxicity studies revealed that EETP is safe up to 2000 mg/kg, with no mortality or observable toxic effects. Antiarthritic activity was assessed using parameters such as body weight, paw volume, mechanical withdrawal threshold, and thermal withdrawal latency in arthritic rats. EETP treatment showed dose-dependent improvement across all parameters. At 400 mg/kg, EETP significantly restored body weight, reduced paw edema, and improved both mechanical and thermal hyperalgesia, comparable to the standard drug Diclofenac. The findings suggest that EETP possesses significant anti-inflammatory and anti-nociceptive properties, supporting its potential as a therapeutic agent in the management of...
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Posted by admin on Mar 31, 2026 in |
The development of anthelmintic resistance and the higher expense of traditional anthelmintic medications caused the Zingiber stigation of medicinal plants as a potential substitute of anthelmintics, utilizing the P. posthuma adult earthworm. The present investigation focuses on the anthelmintic potential of three traditionally used plants of Bangladesh: Zingiber officinale (family: Zingiberaceae), Momordica charantia (family: Cucurbitaceae), and Moringa oleifera (family: Moringaceae) at all tested concentrations (25 mg/ml, 50 mg/ml, and 100 mg/ml), the extracts showed anthelmintic activity. The greatest effect was seen at 100 mg/ml. At higher concentrations, Momordica charantia (Korola) showed the strongest anthelmintic effect among the plants, followed by Zingiber officinale (Ada) and Moringa oleifera (Sajna pata). The traditional use of these plants as natural anthelmintic agents is supported by these...
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Posted by admin on Mar 31, 2026 in |
The search for safer alternatives to synthetic neuroactive drugs has increased interest in medicinal spices with potential central nervous system (CNS) activity. Trachyspermum roxburghianum, a traditionally used aromatic spice, remains poorly explored for its neuropharmacological effects. This study evaluated the CNS depressant activity of the methanolic extract of T. roxburghianum seeds in mice. CNS depressant activity was assessed using forced swimming test (FST), tail suspension test (TST), and thiopental sodium-induced sleeping time assay in Swiss albino mice. The extract was administered orally at doses of 50, 100, and 200 mg/kg, while diazepam (1 mg/kg, i.p.) served as the reference standard. Acute oral toxicity was evaluated up to 2000 mg/kg. Qualitative phytochemical screening was performed, and statistical analysis was conducted using paired Student’s t-test (one-tailed). The extract produced a dose-dependent increase in immobility time in both FST and TST. In the thiopental-induced sleeping time test, the extract significantly reduced sleep onset latency and prolonged sleep duration at higher doses. Phytochemical analysis confirmed the presence of flavonoids, terpenoids, saponins, phenolics, tannins,...
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Posted by admin on Mar 31, 2026 in |
Inflammation is a protective biological response; however, its chronic manifestation is closely associated with the development of several pathological conditions. The limitations and adverse effects of existing anti-inflammatory drugs necessitate the search for safer and more effective alternatives. In the present study, a series of novel heterocyclic derivatives of 2-thiouracil were designed, synthesized, and evaluated for their in-vitro anti-inflammatory activity. Twelve Schiff base derivatives (6a–6l) were synthesized through sulfonylation, hydrazinyl substitution, and subsequent condensation with various substituted aromatic aldehydes. The synthesized compounds were characterized by melting point determination, elemental analysis, and physicochemical evaluation. In-vitro anti-inflammatory activity was assessed using inhibition of albumin denaturation and human red blood cell (HRBC) membrane stabilization assays, with aspirin serving as the reference standard. All tested compounds exhibited concentration-dependent anti-inflammatory activity. Among them, derivatives 6h and 6b demonstrated the most significant inhibition of protein denaturation and superior membrane stabilization activity, approaching the efficacy of aspirin at higher concentrations. Structure–activity relationship analysis suggested that electron-donating substituents and halogen substitution patterns play a crucial role in...
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