Posted by admin on Nov 30, 2025 in |
Irvingia gabonensis is a medicinal plant valued in African traditional medicine for its diverse therapeutic uses. This study focused on the ethyl acetate extract of its stem bark to isolate and identify its major bioactive constituent using modern chromatographic and spectroscopic techniques. Extraction of the powdered stem bark with ethyl acetate produced a 5.30% yield. Thin-layer chromatography (TLC) suggested the presence of several phytochemical components, and subsequent column chromatography led to the isolation of a prominent compound labeled TSM 01. TLC analysis confirmed its purity by showing a single, well-defined spot when sprayed with visualizing agents. The structure of TSM 01 was elucidated using a combination of Fourier Transform Infrared (FTIR), Proton and Carbon-13 Nuclear Magnetic Resonance (¹H-NMR and ¹³C-NMR), Gas Chromatography–Mass Spectrometry (GC–MS), and Liquid Chromatography–Mass Spectrometry (LC–MS). The FTIR spectrum showed characteristic peaks for hydroxyl and carbonyl functional groups, while NMR spectra revealed features typical of a symmetrical aromatic compound. The GC–MS and LC–MS data both displayed a molecular ion peak at m/z 302, consistent with a...
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Posted by admin on Nov 30, 2025 in |
The antihelmintic activity of Nigella sativa (family: Ranunculaceae), Lawsonia inermis (family: Lythraceae) and Syzygium cumini (Family: Myrtaceae) was studied against adult earthworms (Pheretima posthuma). The extract showed anthelmintic activity at the doses of 25 mg/ml, 50 mg/ml, and 100 mg/ml, although the reference standard used was albendazole (10 mg/ml). But the 100 mg/ml had the higher strong anthelmintic effect. Nigella sativa, Lawsonia inermis and Syzygium cumini caused paralysis and death of the earthworms at this concentration in about 7 and 37, 25 and 55 and 61 and 101 min, respectively. However, the extract of Nigella sativa at 100 mg/ml induced paralysis and death at about 7 and 37 min,...
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Posted by admin on Oct 31, 2025 in |
The present study indicates that the development of sunscreen by incorporating natural ingredients obtained from Phyllanthus emblica results in overcoming the side effects of chemically synthetic formulations. The Indian gooseberry, Phyllanthus emblica Linn, is a deciduous tree of the Euphorbiaceae family. The fruit of P. emblica is most widely used herbal drugs in Ayurvedic and Unani systems of medicine. Its chemical constituents include tannin (emblicanin A and B), phenol (gallic acid, ellagic acid), vitamins (ascorbic acid, niacin, thiamine, riboflavin), flavonoids (rutin, quercetin, kaempferol), and alkaloids (phyllantin, phyllembein), among others. Major formulations of Phyllanthus emblica, such as powder, oils, and candy, containing quercetin and emblicanin constituents, show biological potentials including antioxidant, hepatoprotective, anti-inflammatory, and neuroprotective properties, among others. Sunscreens were the best alternatives to prevent sunburns or to protect the skin from the damaging effects of UV rays. The herbal ingredients in the formulation were safe to use as they contain natural substances having fewer side effects, are renewable sources, are under the GRAS (Generally Regarded as Safe) category, and...
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Posted by admin on Oct 31, 2025 in |
Tapinanthus bangwensis is a hemiparasitic plant of the Senegalese flora found in several host plant species such as Combretum micranthum. These two species are used in traditional medicine against several diseases. The aim of this study was to conduct a comparative study between the parasitic plant (Tapinanthus bangwensis) and its host (Combretum micranthum) with regard to their chemical composition and antioxidant activity. Phytochemical screening of the two plants leafy stems were carried out by coloring and/or precipitation reactions. The total polyphenol contents were evaluated by the Folin-Ciocalteu reagent and the flavonoid content by a method using aluminium chloride (AlCl3) and sodium nitrite (NaNO2). As for the antioxidant activity, it was evaluated by DPPH and FRAP methods. The same chemical groups were identified in both plants. However, T. bangwensis was richer in total polyphenols than C. micranthum with respective contents of 145.85±6 and 120.08±2.62mgEAG/g of dry extract. Thus, T. bangwensis extract showed more antioxidant activity than C. micranthum extract with respective IC50 of 3.49±0.06 µg/ml and 6.32±0.05 µg/ml. The parasitic...
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Posted by admin on Sep 30, 2025 in |
Sore throat is acute inflammation of the pharynx and/or palatine tonsils, usually caused by an infection (viral or bacterial) and which frequently leads to the inappropriate use of antibiotics. In the context of antimicrobial resistance, herbal medicines, which contain multiple bioactive compounds, may offer alternatives. Hence, this study was conducted to evaluate the clinical efficacy and tolerability of a Cymbopogon giganteus Chiov (Poaceae) essential-oil oropharyngeal spray previously characterized for in-vitro and in-vivo antimicrobial activity. A single-arm phase 2 clinical trial was conducted at the Suru-Léré University Hospital Center, on adult aged 18 to 65 years with physician-diagnosed uncomplicated sore throat. Participants received the oropharyngeal spray for 7 days on an outpatient basis. Clinical efficacy was assessed using the main specific clinical signs observed on days 3 and 7 with a pre-established score. A total of 39 patients were enrolled. Rapid and substantial symptom reduction was observed by day 3 and maintained on day 7, yielding a final clinical success rate of 94.4%. Adverse events were limited to mild, transient...
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