Posted by admin on Feb 28, 2026 in |
People worldwide have long sought effective ways to alleviate pain, a major symptom of many clinical conditions. To achieve better pain control, there is a continuous need to discover new and effective therapeutic agents. Lime peels (Citrus aurantifolia) have been traditionally used to manage various ailments, including pain and infections, and have also been reported to protect several vital organs. Preliminary phytochemical screening and oral acute toxicity studies were conducted on Citrus aurantifolia peels extract (CAPE). No mortality was recorded during the acute toxicity study; therefore, the LD₅₀ of CAPE was estimated to be greater than 2000 mg/kg. In the acetic acid–induced writhing test, CAPE produced significant (p < 0.001) and non–dose-dependent inhibition of pain, with percentage reductions of 56.9%, 66.5%, and 64.9% at doses of 100, 200, and 400 mg/kg, respectively. In the formalin-induced pain model, CAPE at 200 and 400 mg/kg significantly (p < 0.001) reduced paw-licking time in both the first and second phases. In addition, CAPE significantly increased latency time (area under the curve) and...
Read More
Posted by admin on Feb 28, 2026 in |
The present study aimed to formulate and evaluate a polyherbal capsule using aqueous extracts of Vinca rosea, Curcuma longa, and Dalbergia sissoo. Plant materials were collected, authenticated, dried, and extracted using a traditional aqueous extraction method. Pre-formulation studies were conducted to assess powder flow properties, including bulk density, tapped density, Carr’s index, Hausner’s ratio, and angle of repose. Six formulations (PC1–PC6) were prepared by wet granulation and filled into size “0” hard gelatin capsules using a manual plate method. The capsules were evaluated for organoleptic characteristics, weight variation, disintegration time, moisture content, drug content, in-vitro dissolution, and stability under varying temperature and humidity conditions. Among all formulations, PC1 exhibited superior flow properties, uniform weight, rapid disintegration, and maximum drug release (94.77% at 30 minutes). Stability studies revealed good stability under ambient and moderately elevated temperatures, while degradation occurred at higher temperature and humidity. Overall, the results demonstrate that the developed polyherbal capsule is pharmaceutically acceptable, stable under recommended storage conditions, and holds promise for effective oral herbal...
Read More
Posted by admin on Feb 28, 2026 in |
Vitex madiensis, consumed daily as a tea named Tikoni, is widely used in traditional medicine in Congo Brazzaville to treat fever, pain, inflammation, malaria, dysentery, female infertility, mental illness and epilepsy. Its aqueous leaf extract does not exhibit acute toxicity. Its pharmacological effects against pain, inflammation, insomnia, oxidative stress, and Plasmodium falciparum are very promising. The objective of this study was to investigate the subchronic toxicity of its aqueous extract at a dose of 200 mg/kg orally in Wistar rats over 42 days. Toxicity assessments were conducted on days 14, 28, and 42. The results show that the Tikoni tea aqueous extract does not significantly reduce body weight gain and the growth of certain vital organs. However, liver and lung weights in males, and liver and spleen weights in females, decreased significantly. This extract decreased platelet counts in both sexes and significantly increased leukocyte counts in males. ALT and ALP activities increased significantly in males, while in females, AST, ALT, and ALP activities decreased significantly, and blood glucose levels...
Read More
Posted by admin on Feb 28, 2026 in |
The present study evaluates the antidiabetic potential of hydroalcoholic extracts derived from the fruit and peel of Ananas comosus (pineapple). Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired insulin secretion or action. Natural plant-based remedies have gained attention for their efficacy and minimal side effects. The hydroalcoholic extracts were prepared using standardized extraction methods and subjected to phytochemical screening to identify bioactive constituents. The antidiabetic activity was assessed using in-vivo models of diabetes induced in experimental animals. Blood glucose levels and body weight were monitored throughout the treatment period. Results demonstrated a significant reduction in fasting blood glucose levels and improvement in lipid profile in animals treated with both fruit and peel extracts, with peel extract exhibiting comparatively higher efficacy. The findings suggest that Ananas comosus hydroalcoholic extracts possess promising antidiabetic properties, potentially attributable to their rich phytochemical content, including flavonoids, phenolics, and enzymes. These results warrant further studies to isolate specific active compounds and elucidate underlying mechanisms for clinical application in diabetes...
Read More
Posted by admin on Feb 28, 2026 in |
Background and Aim: Phenanthrene is an aromatic compound with three benzene rings forming the main structure. It represents the majority of polycyclic aromatic hydrocarbons found in the environment and is found in a variety of areas including, burnt smoky coal particles soil and sediment, diesel emissions, tobacco and food smoke. The aim of the study was to determine the effect of phenanthrene on oxidative stress markers in male Wistar rats. Methodology: Fifty healthy rats weighing between 100 and 180g were used for this study. The animals were randomly assigned into five groups of ten rats per group. Group A served as control and the animals were administered with 1ml of DMSO oil only orally for three weeks. Groups B animals were administered orally with 5mg/kg of phenanthrene dissolved in 9ml of DMSO oil and Group C animals were administered orally with 10mg/kg of phenanthrene dissolved in 13ml of DMSO oil for three weeks. Group D animals, had 180mg/kg of phenanthrene dissolved in 1ml of DMSO oil orally, once, while...
Read More
