STUDY OF ANTIARTHRITIC ACTIVITY OF TEPHROSIA PURPUREA L. IN EXPERIMENTAL ANIMALS
AbstractThe present study evaluated the antiarthritic activity of the ethanol extract of Tephrosia purpurea (EETP) in experimental animal models. Acute oral toxicity studies revealed that EETP is safe up to 2000 mg/kg, with no mortality or observable toxic effects. Antiarthritic activity was assessed using parameters such as body weight, paw volume, mechanical withdrawal threshold, and thermal withdrawal latency in arthritic rats. EETP treatment showed dose-dependent improvement across all parameters. At 400 mg/kg, EETP significantly restored body weight, reduced paw edema, and improved both mechanical and thermal hyperalgesia, comparable to the standard drug Diclofenac. The findings suggest that EETP possesses significant anti-inflammatory and anti-nociceptive properties, supporting its potential as a therapeutic agent in the management of arthritis.
Article Information
11
311-320
538 KB
11
English
IJP
Umesh Nigam *, S. C. Mehta and Ranjeet Singh Kushwah
Shri Ramnath Singh Institute of Pharmaceutical Science & Technology, Sitholi, Gwalior, Madhya Pradesh
mspharma8081@gmail.com
21 March 2026
15 April 2026
19 April 2026
10.13040/IJPSR.0975-8232.IJP.13(4).311-20
30 April 2026
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