Posted by admin on May 15, 2026 in |
A series of novel benzoxazole derivatives (4a–4i) were designed, synthesized, and evaluated for their in-vitro antifungal activity against seven phytopathogenic fungi, including G. saubinetii, T. cucumeris, S. sclerotiorum, V. dahliae, F. oxysporum, P. capsici and F. proliferatum, using the mycelial growth inhibition method. All compounds were initially screened at 100 mg/L, and active compounds were further assessed for EC₅₀ values. The synthesized derivatives showed moderate to excellent antifungal activity, with compound 4g exhibiting the most potent and broad-spectrum inhibition, outperforming standard fungicides mandipropamid and hymexazol. Compounds 4f and 4h also displayed strong activity against selected fungal strains. Structure–activity relationship analysis indicated that halogen substitution significantly influenced antifungal efficacy. The results suggest that benzoxazole-based scaffolds, particularly compound 4g, represent promising leads for the development of new antifungal agents for agricultural...
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Posted by admin on May 15, 2026 in |
Medicinal plants are an invaluable source of bioactive compounds with therapeutic potential. Pedalium murex, commonly known as “Gokhru,” has been traditionally used in Ayurveda for managing urological disorders, reproductive health, and inflammatory conditions. This study aimed to perform a comprehensive phytochemical investigation, extraction, and quantification of bioactive constituents in the hydro-alcoholic extract of P. murex leaves. Organoleptic, physicochemical, and preliminary phytochemical evaluations confirmed the presence of carbohydrates, proteins, flavonoids, glycosides, terpenoids, and phytosterols, while saponins, tannins, and alkaloids were absent. The extract yield was 11.87% w/w, and HPLC analysis enabled the identification and quantification of flavonoids, with quercetin and rutin detected at retention times of 2.597 ± 0.08 min and 7.621 ± 0.53 min, respectively. Method validation demonstrated excellent linearity, precision, accuracy, and sensitivity, indicating the reliability of the developed RP-HPLC method for routine quality control. These findings validate the traditional use of P. murex and establish a scientific basis for its standardization, providing a foundation for the development of herbal formulations and nutraceutical...
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Posted by admin on May 15, 2026 in |
Orthosiphon thymiflorus (Roth) Sleesen (Lamiaceae), locally known as “Kattuthritha” or “Neer-naadan,” is a perennial herb valued in South Indian and Southeast Asian traditional medicine for its diuretic, anti-inflammatory, and anti-diabetic properties. Despite its ethnopharmacological relevance, comprehensive pharmacognostic standards for this species are lacking, hindering quality control and authentication. This study addresses this gap by establishing detailed pharmacognostic, physicochemical, and phytochemical profiles for the whole plant. Authenticated plant material underwent macroscopic and organoleptic evaluation, microscopic analysis of leaf, stem, and root transverse sections, and powder microscopy. Physicochemical parameters were determined per WHO guidelines. Preliminary and quantitative phytochemical analyses were performed on chloroform and ethanolic extracts. Macroscopic findings confirmed characteristic Lamiaceae features: quadrangular stems and opposite, ovate-lanceolate, serrate leaves. Microscopy revealed a dorsiventral leaf structure, diacytic stomata, glandular trichomes, and collateral vascular bundles. Physicochemical values included total ash (8.5% w/w), acid-insoluble ash (2% w/w), water-soluble extractive (4% w/w), alcohol-soluble extractive (2% w/w), and loss on drying (1.29 g). Phytochemical screening identified phenols, flavonoids, and triterpenoids, with ethanolic extracts exhibiting a richer...
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Posted by admin on May 15, 2026 in |
The growing costs to society and the economy of neurodegenerative illnesses like Parkinson’s and Alzheimer’s, as well as the hunt for natural compounds with neuroprotective properties. Guapira costaricana and Quercus laurifolia have a long history of medicinal usage. Numerous polyphenols and flavonoid chemicals found in Quercus laurifolia have been studied in depth for their anti-inflammatory and antioxidant qualities. The two major pathogenic elements of neurodegeneration, oxidative stress and neuroinflammation, are reversed by the bioactive substances. The key mechanisms of action in neuroprotection cholinesterase inhibition, mitochondrial guarding, and the modulation of pro-inflammatory cytokines are promisingly demonstrated by experimental data from related species of the Quercus genus. Although little studied, Guapira costaricana has shown pharmacological action that is compatible with neuroprotection, including anti-inflammatory and antioxidant properties. Triterpenes, flavonoids, and alkaloids have been found in the Guapira genus by phytochemical screening. These compounds may have an impact on neural pathways to reduce oxidative neuronal damage and improve synaptic...
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Posted by admin on May 15, 2026 in |
Diabetes mellitus is a major public health challenge worldwide, particularly in sub-Saharan Africa where conventional therapeutic resources remain limited. In Ivory coast, the use of medicinal plants in the management of diabetes remains widespread despite advances in modern medicine. This study aims to evaluate the antidiabetic potential of two Ivorian medicinal plants, Terminalia catappa L. (Combretaceae) and Senna occidentalis (L.) Link (Fabaceae), through phytochemical analyses, antioxidant assays, and in-vivo pharmacological tests. Phytochemical screening revealed the presence of flavonoids, coumarins, sterols, terpenes, and tannins in all tested extracts. Extracts derived from T. catappa leaves stood out for their particularly high levels of total polyphenols and condensed tannins. Assessment of antioxidant activity revealed a significantly high free radical scavenging capacity for the ethanolic and hydroethanolic extracts of T. catappa (extracts Ca3 and Ca4), with respective CR₅₀ values of 0.0316 and 0.0318 mg/ml. In-vivo tests demonstrated that extracts from both plants significantly (p < 0.05) reduce glucose-overload-induced postprandial hyperglycemia, with efficacy comparable to that of low-dose glibenclamide. These results provide a solid...
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