Posted by admin on Apr 30, 2025 in |
Plants have been used for medical purposes since prehistoric periods. Approximately 60% of the world population and 80% of the population of developing countries depend on traditional medicinal plants due to their safety, accessibility, affordability and they are more economic. Inflammation of the joints is known as arthritis. More than 100 distinct forms of arthritis and associated disorders that affect the joints are referred to as arthritis, which is not a single illness. The connective tissue that envelops joints and other tissues. Anti- arthritic activity was mainly reducing the total leukocyte migration as well as lymphocyte and the monocytes / macrophage migration. The current study was designed to evaluate the in-vitro anti- arthritic activity of various extracts like Pet ether, Chloroform, Ethanol, Aqueous of Ficus auriculata Lour leaves. The extraction was done by using Soxhlet apparatus method (Pet ether, Chloroform, Ethanol) and maceration method was done for aqueous extract and the extract was subjected to phytochemical screening. The in vitro anti arthritic activity of various extracts was performed by...
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Posted by admin on Apr 30, 2025 in |
The complication most feared by diabetics remains the diabetic foot, due to the risk of amputation. Terminalia ivorensis belongs to the Combrétacée family and is rich in secondary metabolite products. Studies have shown that Terminalia ivorensis has antifungal potentiaĺ and is traditionally used to treat wounds. Topical application based on Terminalia ivorensis on wounds of rats rendered diabetic showed a rapprochement between the results given by this application and L-mesitran® used as a reference molecule. The aqueous extract at different concentrations (500, 1000 mg/ml) showed significant healing activitý after topical administration in...
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Posted by admin on Apr 30, 2025 in |
Ficus mucuso Welw. ex Ficalho (Moraceae) is a plant used to treat the after-effects of strokes in Côte d’Ivoire. The aim of the present work is to characterize the physicochemical properties of the stem bark of this plant drug, evaluate its anti-inflammatory properties and determine the presence of minerals of interest in post-stroke treatment. Minerals play a crucial role in stroke prevention and management. Physicochemical tests revealed that Ficus mucuso stem bark has a pH of 5.81, a fairly low average water content (7.98%), a relatively high average dry matter content (92.02%), an ash content of 9.21%, and is rich in iron, potassium, magnesium and calcium, important minerals in stroke prevention and management. EAq has the highest concentrations of Potassium (160±11.3 mg/L) and Calcium (11±1.05 mg/L), while EEt has the highest concentrations of Magnesium (2.3 ± 0.12 mg/L) and Iron (1.38 ± 0.04 mg/L). Ficus mucuso stem ecore extract also has anti-inflammatory activity. Aqueous and ethanolic extracts of Ficus mucuso stem bark induce inhibition of protein denaturation at concentrations...
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Posted by admin on Apr 30, 2025 in |
This study is aimed at investigating/elucidating the molecular structure and the biochemical mechanism of anti-inflammatory action of an isolated but yet unknown bioactive compound CA1 from Crateva adansonii stem bark extract. Qualitative phytochemical tests on the isolated bioactive anti-inflammatory compound gave positive reaction to terpenoid only, while the structural elucidation indicates that CA1 is (3β)-lup-20(29)-en-3-ol, a pentacyclic triterpene with molecular weight of 426.70 g, and molecular formular of C30H50O. The molecular structure of this pentacyclic triterpene was established using nuclear magnetic resonance (NMR), ultra-violet/visible spectrophotometer, infra-red, gas and mass spectrophotometers. The (3β)-lup-20(29)-en-3-ol was subjected to in-vivo anti-inflammatory activity study using egg-albumin induced rat hind paw edema method. However, (3β)-lup-20(29)-en-3-olwas investigated for its selective COX-1 and COX-2 inhibitory activities. An in-vitro model of inflammation using a colourimetric COX (ovine) inhibitor screening assay method was used as a model to investigate the effect of CA1 on PGE2 production. (3β)-lup-20(29)-en-3-ol at the tested concentrations significantly (P < 0.05) and selectively inhibited the inducible form of cyclooxygenase, cyclooxygenase-2 enzyme, but exhibited no inhibitory...
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Posted by admin on Apr 30, 2025 in |
Ginger (Zingiber officinale) is one of the most studied medicinal plants, and its bioactive compounds, especially alkaloids, have been demonstrated to possess intense pharmacological activities. We aimed to identify and quantify the major alkaloids present in ginger rhizomes, using phytochemical screening, spectrophotometric analysis and high-performance liquid chromatography (HPLC). The authenticated fresh ginger rhizomes were processed by methanol extraction, which produced 0.704% (w/w) crude extract. In qualitative tests (Mayer’s, Wagner’s, and Dragendorff’s reagents) alkaloids were confirmed; and in spectrophotometric tests, total alkaloid content was determined (18.45 ± 1.27 mg of atropine equivalents/g of extract). In addition, we also analyzed constituents of ginger and found four principal alkaloids of HPLC as follows: 6-gingerol (10.73 ± 0.85 mg/g), 6-shogaol (10.42 ± 0.47 mg/g), 8-gingerol (3.81 ± 0.32 mg/g) and 10-gingerol (3.45 ± 0.43 mg/g). The calibration curves (r²>0.95) for these compounds were excellent, indicating reliability of the method. The high contents of 6-gingerol and 6-shogaol are associated with their well-known anti-inflammatory, antioxidant and anticancer effects, whereas those of 8- and 10-gingerol add to those are presented...
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