Posted by admin on Dec 1, 2022 in |
Objective: This study aim’s to deal with the in vitro anticancer activity of flowers of Couroupita guianensis (family: Lecythidaceae) against B16F10 (skin cancer cell line). Materials and Methods: MTT assay for flowers of Couroupita guianensis against B16F10 (Skin Cancer cell line) is conducted. Results: At the Concentration 44.44 µg/ml, the methanolic flower extract of Couroupita guianensis showed good percent inhibition of B16F10 (Skin Cancer cell line) as compared to the standard drug. Conclusion: The present attempt provides information that may generate researchers’ interest in exploring such natural...
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Posted by admin on Dec 1, 2022 in |
Caesalpinia sappan L. is a member of the Caesalpiniaceae family. It originated from India through Myanmar and Thailand to peninsular Malaysia to Indochina and south china. It is also called Brazilin. The heartwood of Caesalpinia sappan contains water soluble properties that color to transform into the red. When oxidation process occurred. The chemical constituents investigation of sappan wood resulted that it has phenolic components, including one xanthine, one coumarin, three chalcone, 2 flavones, three homoisoflavonoid and Brazilin. The traditional Chinese medicine brazilin is used to treat increased blood circulation, promote menstruation, and exhibit analgesic property. The article aims to review the pharmacognostic study of Caesalpinia sappan and explore its pharmacological properties such as antioxidant activity, antibacterial activity, antiacne activity, anti-inflammatory activity, hepatic-protective, anticancer activity, and larvicidal...
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Posted by admin on Dec 1, 2022 in |
Public health challenge due to respiratory tract infections has necessitated vehement research for promising substances against the causative agents. The leaves of Eucalyptus citriodora (E. citriodora, Myrtaceae) are used in Nigeria as tea, infusion or steam inhalation by patients as an alternative medicine to clear the airway and relieve symptoms; however, no scientific evidence exists to support or debunk this claim. This study aimed to evaluate the in-vitro antimicrobial effect of E. citriodora leaf essential oil and crude extracts against selected pathogens implicated in respiratory tract infections. The fresh leaves of E. citriodora were collected, identified and subjected to exhaustive fractionated extraction. The leaf essential oil was obtained by hydrodistillation using Clevenger-type apparatus and characterized using GC-MS. Aqueous extracts were obtained by hot infusion and decoction and characterized using HPLC-UV-DAD. The susceptibility of test pathogens Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Salmonella paratyphi ATCC 9150 Candida albicans ATCC 10231, Klebsiella pneumonia and Streptococcus pneumonia to the extracts were evaluated by agar well diffusion...
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Posted by admin on Dec 1, 2022 in |
Lamium amplexicaule L. is a genus of the family Lamiaceae. This plant species has been used widely in traditional medicines to treat many disorders. Phytochemical screening (qualitative and quantitative), antioxidant capacity, total phenol, and total flavonoid content were analyzed in a crude extract of leaves. The extract was prepared in aqua-methanol and aqua acetone in 30:70. Antioxidant capacity was analyzed in both extracts through (2,2-diphenyl-1picrylhydrazyl (DPPH) Free Radical Scavenging Assay, FRAP (Ferric Ion Reducing Antioxidant Potential), FCA (Fe2+ Ion Chelating Activity), Phosphomolybdenum assay (TAA), Total Phenol Content (TPC) and Total Flavonoid Content (TFC). Both extracts showed the presence of tannins, alkaloids, flavonoids, proteins, phenols, saponins, terpenoids, carbohydrates, quinones, oils, and resins. The result for antioxidant assay (DPPH, FRAP, FCA and TAA) was comparatively higher in aqua-methanol than in aqua-acetone. TFC values were higher in aqua-acetone, while TPC in aqua-methanol extract. Thus, the plant species can be used as a potent source of ayurvedic...
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Posted by admin on Aug 31, 2022 in |
Background: The current study was conducted at the department of veterinary pharmacology and toxicology to assess the impact of Emblica officinalis on oxidative stress produced by sub-acute enrofloxacin exposure in albino rats. Methodology: Albino rats weighing 200-300 grams were given enrofloxacin and Emblica officinalis orally through gavage needle. Blood samples were taken via capillary tube on the 28th day of the experiment and analyzed using laboratory procedures. Result: Sub-acute treatment of enrofloxacin at doses of 5 mg/kg b.wt. and 10 mg/kg b.wt. generated oxidative stress in rats, as evidenced by substantial changes in oxidative parameters, and affected liver and kidney functions, as seen by changes in biochemical markers of liver and kidney function. Emblica officinalis aqueous extract (200 mg/kg b. wt.) effectively reduces oxidative stress and changes in hepatic and renal function caused by enrofloxacin. Conclusion: Emblica officinalis (Amla) has antioxidant properties and can reduce oxidative stress caused by enrofloxacin in albino rats following sub-acute...
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