Posted by admin on May 31, 2024 in |
The present work focused on preparing ethanolic extract of Nymphae nouchali flower and evaluating its anti-diabetic potential in rats. The extraction of flowers was carried out using ethanol and the extraction yield was found to be 18.6% w/w. The result of the total phenolic content of the extract examined using Folin-Ciocalteu method revealed total phenolic content of ethanolic extract of Nymphae nouchali was 41.26 ± 2.13 GAE mg/g. The antidiabetic action of the extract was evaluated in terms of the effect of extract on body weight and serum glucose level. It was found that alloxan administration reduced the body weight of animals significantly in comparison with the normal control animals. The results also revealed that the serum glucose levels were highly elevated by the administration of alloxan in all the groups by day 7. In the treatment groups III to V, the glucose levels dropped in comparison to group II and by day 21, the levels reached almost the level of control group in group III and V. This...
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Posted by admin on Apr 30, 2024 in |
Since time immemorial, natural products have been the backbone of traditional system of healing throughout the globe and have also been an integral part of history and culture. Hence Baphia pubescence has been used ethnomedicinally to treat various diseases. The leaf or leaf juice is applied against parasitic skin diseases. A leaf infusion is drunk to cure enteritis and other gastrointestinal problems. The leaves and bark are considered haemostatic and anti-inflammatory and are used for healing sores and wounds. The leaves infusion is used to treat malarial infections as well as other microbial infections. As a result, it is pertinent to study the toxicity of the plant. The toxicological study both acute and chronic were evaluated according to standard methods. Acute andChronic toxicity studies of B. pubescens indicated that the plant is relatively safe at the therapeutic dose. The toxicity of the plant was shown to be dose dependent. The kidney and liver enzymes increased with increasing doses whereas the histopathological damage after long administration on these organs was...
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Posted by admin on Feb 29, 2024 in |
Fast dissolving or mouth disintegrating tablets are oral delivery systems intended for a rapid breakdown of the dosage form in the mouth or oral cavity, in contrast to other conventional dose forms. Labetalol, an alpha-1-adrenergic antagonist of the third generation, has vasodilatory and antihypertensive properties. It is used to treat hypertension and angina. Using novel co-processed super disintegrants and physical combinations combining croscarmellose and crospovidone in 1:1, 1:2, 1:3, 2:1, and 3:1 ratios, this study attempts to produce and evaluate labetalol fast dissolving tablets. The direct compression method was used to make the tablets. The tablets work instantly since they dissolve quickly when used orally. Like liquid dosage forms, orally disintegrating tablets are easier to take and offer greater convenience. Important excipients called disintegrants are added to solid dosage forms in order to break or disintegrate tablets in aqueous media. The disintegrants enhance the formulation’s surface area, or tablet’s surface area, and counteract the cohesive forces that hold the particles...
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Posted by admin on Feb 29, 2024 in |
Objectives: Silymarin is an anti-inflammatory agent that is used in the treatment of a variety of inflammatory disorders. The aim of the present study was to prepare and evaluate novel polymeric nanoparticles containing Silymarin. Materials and Methods: A 32 full factorial design was used to study the effect of Eudragit EPO and Pluronic F-68 on the characterization of nanoparticle suspensions. The polymeric nanoparticles were prepared by Nano precipitation technique. The prepared nanoparticles was evaluated by percentage yield, drug polymer compatibility using Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetric (DSC) analysis, drug content, entrapment efficiency, zeta potential, particle size, scanning electron microscopy, X-ray diffraction, in-vitro drug release studies, kinetic modelling, stability studies, and in-vivo animal studies. Results: The DSC study revealed that the drug was involved in complexation with nanoparticles. The average particle size of Silymarin nanoparticles was in the range of 114.4 nm to 136.7 nm. The zeta potential values were attained to ensure good stability of nanosuspensions. In-vitro release of the drug from nanoparticles follows the...
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Posted by admin on Jan 31, 2024 in |
Medicine presently used to deal with cough are the various maximum notably used over the counter drug treatments in the international, in spite of a recent evaluation suggesting that there is a bit evidence to comparable drug treatments produce any significant efficiency. Syrup is commonly useful and famous dosage form which is used for the remedy of cough and bloodless. We organized the herbal cough syrup by means of including Jaggery base and decoction of natural capsules together with Pudina, Tulsi, Cinnamon, Jaggery and other natural excipients. The natural cough syrup is formulated by using decoction method. Including the decoction of natural capsules with base of Jaggery is beneficial to the formulation for thick and preserves the system. That turned into beneficial to increase the shelf lifestyles of components of natural syrup. The brought Jaggery sweetener also can help to growth the palatability of some natural drugs. The ultimately increase the herbal cough syrup with the bottom of Jaggery. The purpose of this examine is to develop a herbal...
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