Posted by admin on Mar 13, 2016 in |
Cinnamon is one of the best-known spices used as herbal medicine. Cinnamaldehyde is the most important constituents of cinnamon. The present study was aimed to evaluate the analgesic activity of Cinnamaldehyde per se and its interaction with diclofenac sodium and pentazocine in Swiss albino mice. Healthy mice of either sex weighing 20-30 grams were divided into 6 groups of 6 animals each. Peripheral analgesic activity was evaluated by acetic acid induced writhing test, and central analgesic activity was studied using Eddy’s hot plate method. Cinnamaldehyde (100 and 200 mg/kg) and its combination (Cinnamaldehyde 100 + 2.5 mg/kg standard drug), diclofenac sodium (2.5 and 5 mg/kg) and pentazocine (2.5 and 5 mg/kg) were given orally. Acetic acid induced writhing model showed that diclofenac sodium at doses of 2.5 and 5 mg/kg reduces writhing 44% and 66% respectively as compared to control when administered alone. Cinnamaldehyde at 100 and 200 mg/kg showed dose-dependent decrease in writhes 54% and 81%, but when Cinnamaldehyde (100 mg/kg) was co-administered with diclofenac sodium (2.5mg/kg) showed...
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Posted by admin on Mar 13, 2016 in |
Diabetes mellitus is a metabolic disorder in the endocrine system. This dreadful disease is found in all parts of the world and is becoming a serious threat to mankind health. There are lots of chemical agents available to control and to treat diabetic patients, but total recovery from diabetes has not been reported up to this date. An alternative to these synthetic agents, plants provide a potential source of hypoglycemic drugs and are widely used in several traditional systems of medicine to prevent diabetes. Several medicinal plants have been investigated for their beneficial use in different types of diabetes. The effects of these plants may delay the development of diabetic complications and correct the metabolic abnormalities using a variety of mechanisms. whole fruit of Momordica charantia was selected in this study to find out the phytochemicals & antidiabetic property. Phytochemicals were extracted using water. For the current article screening of alkaloid, carbohydrates, glycosides, flavonoids, proteins, tannins & phenolic compounds and also done single dose antidiabetic activity. Screening of phytochemicals...
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Posted by admin on Mar 13, 2016 in |
Sonchus arvensis, a perennial sowthistle, is a common but underutilized species of Kathmandu, Nepal. Several uses like sedative, antioxidant and kidney stone eradicating properties have been identified till date, but a study on other pharmacological activities is not yet explored. Therefore, the plant was collected from Kathmandu; aerial parts of the plant were dried, crushed, and extracted using a Soxhlet apparatus. The methanolic extract was then concentrated for screening pharmacological effects. While comparing with the standards, the plant was found to possess potent anti-inflammatory activity and inhibitory effect in Gastro-Intestinal (GI) motility and locomotor activity in a dose-dependent fashion. The plant, however, didn’t show skeletal muscle relaxant activity as observed in the traction test and inclined plane test. Thus, it is concluded that the plant possesses strong phytochemicals having anti-inflammatory activity and inhibitory effect in locomotion and GI...
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Posted by admin on Jan 30, 2016 in |
The global market for herbal products is exploding. The major hindrance in the amalgamation of herbal medicines into modern medical practices is the lack of scientific and clinical data and a better understanding of efficacy and safety of the herbal products. The evaluation or standardization of a crude drug involves Pharmacognostic methods such as organological, physicochemical, phytochemical and pharmacological analysis. The experimental material selected for the present study is Tragia plukenetii R. Smith belongs to the family Euphorbiaceae. This herb is distributed in hill slopes of southern peninsular India. The root is diaphoretic and alternative and is given for fevers to cause perspiration. The present paper deals with anatomical characters of leaf, stem, and roots. The dried powders of stem, leaves and roots and their extracts in various solvents were examined with ordinary light and U.V. light (365nm). Quantitative determination such as moisture content, total ash, water-soluble ash, acid insoluble ash, water extractive values, and sulfated ash have also been made. Preliminary phytochemical analysis of the extracts was done...
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Posted by admin on Jan 30, 2016 in |
The plant of Desmodium triflorum Linn (Fabaceae) is reported to have great medicinal value. The aim of this study to evaluate pharmacognostic evaluation including examination of morphological characters, ash value, powder analysis, and extractive values was carried out. Phytochemical screening including chemical examination and chromatographic study were also carried out. This would help to scientifically justify its pharmacological activities of particular chemical constituents in different...
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