ANALGESIC ACTIVITY OF CINNAMALDEHYDE PER SE AND IT’S INTERACTION WITH DICLOFENAC SODIUM AND PENTAZOCINE IN SWISS ALBINO MICE.Abstract
Cinnamon is one of the best-known spices used as herbal medicine. Cinnamaldehyde is the most important constituents of cinnamon. The present study was aimed to evaluate the analgesic activity of Cinnamaldehyde per se and its interaction with diclofenac sodium and pentazocine in Swiss albino mice. Healthy mice of either sex weighing 20-30 grams were divided into 6 groups of 6 animals each. Peripheral analgesic activity was evaluated by acetic acid induced writhing test, and central analgesic activity was studied using Eddy’s hot plate method. Cinnamaldehyde (100 and 200 mg/kg) and its combination (Cinnamaldehyde 100 + 2.5 mg/kg standard drug), diclofenac sodium (2.5 and 5 mg/kg) and pentazocine (2.5 and 5 mg/kg) were given orally. Acetic acid induced writhing model showed that diclofenac sodium at doses of 2.5 and 5 mg/kg reduces writhing 44% and 66% respectively as compared to control when administered alone. Cinnamaldehyde at 100 and 200 mg/kg showed dose-dependent decrease in writhes 54% and 81%, but when Cinnamaldehyde (100 mg/kg) was co-administered with diclofenac sodium (2.5mg/kg) showed a significant decrease in writhes 84.43% concerning control. While in Eddy’s hot plate method Cinnamaldehyde not only showed hyperalgesia when given alone as compared to control but also decreases the analgesic effect of pentazocine when combined with pentazocine in comparison with pentazocine alone and control group. The findings suggest that the Cinnamaldehyde significantly increases the analgesic activity of diclofenac sodium, but decreases the analgesic activity of pentazocine.
R. Churihar *, P. Solanki, S. Vyas, H. Tanwani and S. Atal
Department of Pharmacology, M.G.M. Medical College, Indore, Madhya Pradesh, India.
14 December 2015
21 January 2016
29 January 2016
29 February 2016