Posted by admin on Nov 14, 2016 in |
The present study mainly focuses on the ethnomedicinal importance of Soymida febrifuga. The selected plant was reported to have wide ethnomedicinal use. The literature revealed that there is a lack of scientific reports on its leaf. So it is important to provide scientific means systematically. The Phytochemical analysis of the plant has stated about the presence of Carbohydrates, cardiac glycosides, Saponin glycosides, flavonoids, steroids, triterpenoids, tannins, phenolics, and fixed oil, etc. The ethnomedicinal documentation confirms about the potent activity of the leaf part of Soymida febrifuga. The present study provides evidence that solvent extract of Holoptelea integrifolia and Celestrus emarginata contains medicinally important bioactive compounds and this justifies the use of plant species as a traditional medicine for treatment of various...
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Posted by admin on Nov 14, 2016 in |
The natural anthracene derivative emodin (1,3,8-trihydroxy-6-methylanthraquinone) is known as an anticancer agent. In the present work, it was isolated for the first time from the ethanol extract of Rumex confertus leaves, widely used in Armenia as a vegetable. It was purified in two-step low-pressure liquid chromatography – a significantly easier and inexpensive procedure compared with those used for emodin purification. The purified preparation was characterized by chemical and TLC analyses, NMR, UV-Vis and fluorescence spectra. Rather high cytotoxicity toward cultivated primary cells of mice Ehrlich ascites carcinoma was demonstrated for both the ethanol extract (IC50 = 0.3 ± 0.04 µg/ml), and emodin (IC50 = 40 ± 10 ng/ml) from Rumex confertus leaves. Along with the anticancer activity, these preparations protected a) hippocampal cells against toxic action of aggregated amyloid Aβ (1-40) and Aβ (1-42) peptides and b) the islet β-cells against death in the presence of aggregated pancreas peptide hormone amylin. The obtained results provide a rationale for developing anticancer, neuroprotective and antidiabetic remedies from the leaves of Rumex...
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Posted by admin on Nov 6, 2016 in |
Calotropis gigantea, belonging to the family of Asclepiadaceae. The plant has the antimicrobial activity, antioxidant activity, analgesic activity, anti-pyretic activity, insecticidal activity, cytotoxicity activity, hepatoprotective activity, purgative properties and wound healing activity. The present paper is an attempt to provide a detailed botanical description, classification, phytochemical and various pharmacological activity study of the...
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Posted by admin on Nov 6, 2016 in |
Natural products and herbal remedies used in traditional folklore medicine have been the source of many medically beneficial drugs because they elicit fewer side effects, relatively cheap, affordable and claimed to be effective. However, in order to make these remedies acceptable to modern medicine, there is a need to scientifically evaluate them to identify the active principles and to understand their mechanism of action. Tephrosia villosa Pers. (Fabaceae) is a medicinal plant widely used as a folk medicine in India. The present study deals with the isolation and partial purification of bioactive compounds from the crude methanol extracts of the leaves of Tephrosia villosa Pers. The quantification and the identification of compounds in the crude extract and active bands isolated by preparative TLC were accomplished using spectroscopic analysis. The most important compounds β-sitosterol identified in the crude extract appreciable amounts may account for its various biological...
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Posted by admin on Nov 6, 2016 in |
The present study aims to standardize Amritarishta based upon chromatographic and spectral studies. The spectral data and HPTLC fingerprint of ethanolic extract of Amritarishta could be used as a valuable analytical tool in the routine standardization of Amritarishta to check the batch to bath variation. Fraction, I and II of ethanolic extract of Amritarishta and standard luteolin and apigenin, were compared by TLC, HPTLC, and HPLC analysis to evaluate the presence of luteolin and apigenin is employing toluene: ethyl acetate: glacial acetic acid (5:4:1 v/v/v), as a mobile phase respectively. The Rf values (0.64) and (0.81) for luteolin and apigenin in both sample and reference standard were found comparable under UV light at 366 nm respectively. The High-Performance Thin Layer Chromatography method developed for quantization was simple, accurate and specific. The present standardization provides a specific and accurate tool to develop qualifications for identity, transparency, and reproducibility of biomarkers luteolin and apigenin in a liquid...
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