ANTIHYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTRACT OF AMORPHOPHALLUS PAEONIIFOLIUS TUBER IN TRITON WR 1339 INDUCED HYPERLIPIDEMIC RATSAbstract
Hyperlipidemia is the most prominent risk factor in coronary heart disease. The present study was designed to investigate the anti-hyperlipidemic activity of Amorphophallus paeoniifolius Tuber in Triton WR-1339 induced hyperlipidemic rats. Amorphophallus paeoniifolius extract was administered at a different dose of 250mg/kg, 500mg/kg (p.o) daily for 7 days to hyperlipidemic rats. Gemfibrozil is used as a reference standard. The statistical analysis was performed by using one way ANOVA followed by the Dunnet’s multiple comparison tests. This is to highlight the presence of the different secondary metabolites, extract by solvents (ethanol) and analyze the content of total phenols from the tuber by the visible UV spectrophotometry method. The results obtained indicate that the tuber of Amorphophallus paeoniifolius contains high concentrations of total phenols (respectively 79, 35 mg GAE/gDM). These polyphenols possess a strong anti-hyperlipidemic activity. Amorphophallus paeoniifolius showed a significant decrease in the levels of serum cholesterol, triglycerides, LDL (low-density lipoprotein), VLDL (very low-density lipoprotein) and the significant increase in the level of serum HDL (high-density lipoprotein) at the dose of 500mg/kg (p.o) against Triton induced hyperlipidemic rats. The objective of our work, frame a valorization of vegetable substances namely Amorphophallus paeoniifolius in the north Indian region. Therefore it effectively suppressed the Triton WR 1339 induced hyperlipidemia in rats, suggesting the potential protective role in Coronary heart disease (C.H.D).
A. Gautam *, P. Verma, S. K. Paswan, I. Shukla and C. V. Rao
Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute (CSIR), Uttar Pradesh, Lucknow, India.
13 November 2016
19 December 2016
26 December 2016
01 January 2017