Posted by admin on Sep 8, 2017 in |
Teucrium polium L. is a member of the Lamiaceae family and is represented in the Flora of Syria by two variety: Teucrium polium var. angustifolium and Teucrium polium var. mollissimum. Teucrium polium is a wild-growing flowering plant, found abundantly in Syria, and it is used traditional medicine for it’s diuretic, antipyretic, antispasmodic, tonic, anti-inflammatory, antihypertensive, anorexic, analgesic, antibacterial and anti-diabetic effects. Several reports have demonstrated a wide range of beneficial biological and pharmacological activities of the phenylethanoid, phenylpropanoid and flavonoid components, while the furano neo-clerodane diterpenoids present in germander have been implicated in the in–vivo hepatotoxicity of this botanical. Phytochemical studies of this plant have been carried out. Aerial parts of the plant were extracted with petroleum ether at room temperature, and then extract with methanol in Soxhlet, and finally extract with aqueous methanol at room temperature successively. Fractionation of the methanol extract by column chromatography and purification by crystallization yielded three known flavonoids cirsimartin, cirsiliol, and apigenin. The aqueous methanolic extract yielded one new neo-clerodane type diterpenoid, syrapolin...
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Posted by admin on Aug 2, 2017 in |
Combretastatin A-4 (CA-4) is an anti-mitotic agent that is gaining rapid recognition among cancer biologists and clinicians as one of the newer vascular disrupting agents, (VDAs) for cancer therapy. CA-4 belongs to a group of tubulin binding natural products called combretastatin, derived from the African Bush Willow, Combretum caffrum. Due to CA-4’s in-vivo efficacy, several analogs of CA-4 have been synthesized to maximize its solubility and bioavailability. Combretastatin A-4 phosphate is a more soluble form of CA-4 that has completed for treatment of acute myelogenous leukemia and relapsed ovarian cancer. This review attempts to highlight the various CA-4 analogs that have been synthesized and their effectiveness in clinical. Combretastatin A-4 phosphate (CA-4-P) is a biologically very active compound by binding to the colchicine binding site which leads to the inhibition of microtubule polymerization as well as showing antiangiogenic and anticancer effects by selectively shutting down the tumor blood flow. To avoid the disadvantage of rather low in-vivo efficacy resulting from the isomerization of the cis-stilbene derivative to the thermodynamically...
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Posted by admin on Aug 2, 2017 in |
Herbal medicines are now creature in modern dosage forms using modern manufacture in and processing techniques in the pharmaceutical industry. Antioxidants assuage oxidative stress in cells and thereby help in the prevention and treatment of many diseases of humans. This study aimed to assess the antioxidant activity of ethanol and chloroform extracts of wild and micro-propagated Cleome viscosa. DPPH performed an antioxidant activity ((2, 2 – diphenyl 1, picryl hydrazyl) radical scavenging method for ethanol and chloroform extracts of wild and micro-propagated C. viscosa. The ethanol and chloroform extract results were exhibited by strong antioxidant DPPH radical scavenging activity with the percentage of potential antioxidant concentration wild and micro-propagated were found to be 77.74%, 76.45% and 63.54%, 55.16% respectively. The percentage compared to positive standard compounds of ascorbic acid. The results were concluded that ethanol extracts possess effective antioxidant activity than that chloroform...
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Posted by admin on Aug 2, 2017 in |
Introduction: Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia. As morbidity and mortality rate from diabetes is increasing on the one hand and the cost of modern medicine is getting higher on the other in low – and middle – income countries, it is necessary to evaluate medicinal plants for their potential therapeutic effects against diabetes. The present study was, therefore, undertaken to evaluate the hypoglycemic and anti-hyperglycemic activity of the leaf extracts of Psidium guajava in normoglycemic and streptozotocin-induced diabetic mice, respectively. Materials and Methods: The aqueous and ethanol extracts of Psidium guajava leaves were prepared following standard procedures. Swiss albino mice of either sex weighing 20-30 grams were used for the experiments. Normal mice were grouped into eight groups to carry out the hypoglycemic effect of the extracts, whereas mice that were made diabetic were grouped into nine groups to study the antihyperglycemic effect of the extracts. Diabetes was induced by streptozotocin (STZ). Blood glucose levels were measured using the glucose oxidase...
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Posted by admin on Jul 11, 2017 in |
Standardization is the need of the hour in Ayurvedic system of medicine. The traditional systems of medicine are really effective but the problem with them is they lack in quality assurance. This enables us to recognise the quality of the formulation. The Central Council of Research in Ayurveda and Siddha has prescribed the preliminary guidelines for testing the quality of these formulations. It is essential to derive a protocol or develop methods for evaluation of herbal formulation to maintain uniformity between batches during production. The present work aims to standardize a poly-herbal churna called Gandharva haritaki Churna available in the market. The churna was procured and standardised for the parameters like organoleptic characters, physical characters, physiochemical properties and phytochemical screening etc. These parameters can determine the quality of the product. The results were found to be within the...
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