Posted by admin on Mar 10, 2017 in |
The toxicity of aqueous extracts of S. siamea leaves, S. latifolius roots collected in Benin and their mixture (1/1, w/w), was evaluated on female non-pregnant rats, Albino wistar genus. They were treated for two weeks, with various extracts administered by the oral way at 2000 mg/kg body weight. The biochemical parameters were determinate, histological analysis of the rats was done, and the urinary concentration of neutral gelatinase-associated lipocalin (NGAL) was measured. The treatment of the rats with different extracts not caused undesirable effects and deaths during the fourteen days of observation. Significant changes are relative of a histological aspect of hepatocyte and renal cortex as well as significant increases in the activity of enzyme serum alanine aminotransferases (ALT) and aspartate aminotransferases (AST). The aqueous extracts at 2000 mg/kg were disrupted some biochemical parameters. These changes were confirmed by the rate raised from NGAL noted in the urine of the treated...
Read More
Posted by admin on Jan 28, 2017 in |
Loganin is an iridoid glycoside, a key phytoconstituent in Strychnos plants having a crucial role in the biosynthesis of indole, monoterpene alkaloids and other natural products. It is a bitter iridoid glycoside with numerous activities like anti-inflammatory, anti-oxidant, glucose-lowering and anti-diabetic nephropathy activities. The objective of this study was to develop a simple method for isolation of loganin from fruit pulp of Nux vomica and quantify by HPLC. The isolated compound was characterized by TLC, UV, IR, MS, and NMR spectral analysis and purity were confirmed by HPLC analysis. Quantification of loganin was done from fruit, seeds and pulp extract using HPLC. A simple solvent partitioning method was used for the extraction and isolation process. This isolation method developed involved easy solvent-solvent extraction technique followed by recrystallization to purify the...
Read More
Posted by admin on Jan 28, 2017 in |
As per the appeal issued by World Health Organization (WHO) “save plants to save lives,” there is the need for a global movement for the conservation of medicinal plants and the revitalization of the native health traditions of local communities. Such health traditions based on medicinal plants are the result of centuries of observation, selection, and experimentation. They thus constitute an accumulated pool of medical wisdom, based on the dictum “an ounce of practice is worth tons of theory.” Unfortunately, such invaluable knowledge and experience are increasingly coming under the category of ‘dying wisdom.’ Throughout human history people have relied on natural products and plants, in particular, to promote and maintain good health and to fight sickness, pain, and disease. The past 200 years have witnessed not only an acceleration in the rate of extinction of plant and animal species but also the erosion of traditional knowledge related to the medicinal properties and uses of the plant and other natural products. India also had a rich tradition for primary...
Read More
Posted by admin on Jan 28, 2017 in |
A study was conducted to assess root, leaves and flowers extracts of Cichorium intybus for their antimicrobial activities (against four bacterial and fungal strains), antioxidants activities (DPPH, ABTS H2O2 and reducing power assays) and cytotoxicities assays. The results indicate remarkable inhibition of plant extracts for the growth of all bacterial and fungal strains as well as appropriate MIC values were observed as compared to standard antibiotics used. The activities of these extracts against four assays like DPPH, H2O2, ABTS, and reducing powder was promising. Whereas the cytotoxic activity of extracts study against brine shrimp was reliable. The phytochemical analysis of the various parts of Cichorium intybus revealed that activities of these extracts might be due to the presence of various secondary metabolites like phenolics and flavonoids those were analyzed with higher quantities from these extracts. Therefore such a study could be useful for the development of new pharmaceuticals that could lead such compounds for the preparation of new medicines required for human and animals...
Read More
Posted by admin on Jan 28, 2017 in |
Hyperlipidemia is the most prominent risk factor in coronary heart disease. The present study was designed to investigate the anti-hyperlipidemic activity of Amorphophallus paeoniifolius Tuber in Triton WR-1339 induced hyperlipidemic rats. Amorphophallus paeoniifolius extract was administered at a different dose of 250mg/kg, 500mg/kg (p.o) daily for 7 days to hyperlipidemic rats. Gemfibrozil is used as a reference standard. The statistical analysis was performed by using one way ANOVA followed by the Dunnet’s multiple comparison tests. This is to highlight the presence of the different secondary metabolites, extract by solvents (ethanol) and analyze the content of total phenols from the tuber by the visible UV spectrophotometry method. The results obtained indicate that the tuber of Amorphophallus paeoniifolius contains high concentrations of total phenols (respectively 79, 35 mg GAE/gDM). These polyphenols possess a strong anti-hyperlipidemic activity. Amorphophallus paeoniifolius showed a significant decrease in the levels of serum cholesterol, triglycerides, LDL (low-density lipoprotein), VLDL (very low-density lipoprotein) and the significant increase in the level of serum HDL (high-density lipoprotein) at the dose...
Read More
