IN VITRO AND IN VIVO TOXICOLOGICAL EVALUATION OF AQUEOUS EXTRACTS FROM BENINESE PLANTS: SENNA SIAMEA LEAVES AND SARCOPCEPHALUS LATIFOLUS STEM ROOTSAbstract
The toxicity of aqueous extracts of S. siamea leaves, S. latifolius roots collected in Benin and their mixture (1/1, w/w), was evaluated on female non-pregnant rats, Albino wistar genus. They were treated for two weeks, with various extracts administered by the oral way at 2000 mg/kg body weight. The biochemical parameters were determinate, histological analysis of the rats was done, and the urinary concentration of neutral gelatinase-associated lipocalin (NGAL) was measured. The treatment of the rats with different extracts not caused undesirable effects and deaths during the fourteen days of observation. Significant changes are relative of a histological aspect of hepatocyte and renal cortex as well as significant increases in the activity of enzyme serum alanine aminotransferases (ALT) and aspartate aminotransferases (AST). The aqueous extracts at 2000 mg/kg were disrupted some biochemical parameters. These changes were confirmed by the rate raised from NGAL noted in the urine of the treated rats.
K. W. Dieu-Donné Agbodjogbe, A. G. Houngbeme *, M. Haïdara, R. Sanogo, A. Laleye and H. P. Dansou
Laboratoire National de Pharmacognosie 3, Institut de Recherche et d’Expérimentation en Médecine et Pharmacopée Traditionnelles (IREMPT), Centre Béninois de Recherche Scientifique et Innovation (CBRSI), Benin
25 November 2016
22 December 2016
26 December 2016
01 February 2017