Posted by admin on May 2, 2018 in |
The drug is obtained from the dried fruit of Nyctanthes arbor-tristis of family Oleaceae. It is also called Coral Jasmine, Parijat, and Harsingar, etc. To confirm the veracity of the claim above, the anticonvulsant effect of the ethanolic extract has been evaluated. In this investigation, the rats were pretreated with different dose of Nyctanthes arbor-tristis ethanolic extract (100, 200 mg/kg) for 14th days and then, they were subjected to maximal electroshock-seizures, the dose of 100 and 200 mg/kg significantly reduced the duration of hind limb extension, and both the doses were statistically found to be equipotent. The reference, standard, Phenytoin (30 mg/kg) provided complete protection. Thus, the present study revealed the anticonvulsant effect of Nyctanthes arbor-tristis against maximal electroshock-induced convulsion in the...
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Posted by admin on May 2, 2018 in |
The present investigation was designed to prepare immediate release tablets of gliclazide with the ultimate aim of reducing the time needed to obtain the peak plasma concentration. Gliclazide immediate release tablets were prepared by using superdisintegrants namely- sodium starch glycolate and croscar-mellose sodium. The prepared tablets were evaluated for weight variation, hardness, friability, and dissolution. Data obtained from in-vitro dissolution tests were employed to zero order kinetic model. All the data were in the acceptable range. Compatibility study was conducted using Fourier transform infrared spectroscopy (FTIR). The drug and all the excipients showed good...
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Posted by admin on May 2, 2018 in |
Alchemilla species (Rosaceae) are locally known as “aslanpençesi” in Turkey. Alchemilla plants (lady’s mantle) are used in traditional medicine for different indications. In this study, the methanol extract of Alchemilla caucasica was analyzed using gas chromatography-Mass Spectrometry, while the mass spectra of the compounds found in the extract were matched with the National Institute of Standards and Technology Library. The study revealed the presence of fourteen phyto-components. The most abundant compounds in the methanol extract were 13-docosenamide (Z)-, 5- octadecenoic acid 2,3-dihydroxy-propyl ester and hexadecanoic acid 2-hydroxy-1-(hydroxyl-methyl) ethyl ester which had concentrations of 59.77%, 15.34%, and 7.59% respectively. Results indicated that polarity of the solvents used in extraction influenced the relative abundance and type of compounds extracted. Various compounds identified are known to have varying bioactivities such as being anticancer and antioxidant. Therefore, the presence of these compounds in Alchemilla caucasica could be useful in the preparation of functional foods and neutraceuticals in preventing and treating debilitating and chronic human...
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Posted by admin on Apr 12, 2018 in |
Anethum graveolens an important medicinal plant and one of the most widely cultivated species of the family (Umbelliferae). It is highly valued from time immemorial because of its vast medicinal properties. The present work deals with the investigation of the laxative activity of various extracts of Anethum graveolens fruits. The laxative effect was checked in using Wister strain Albino rats. All the crude extracts such as ethanol, ethyl acetate, n-butanol and petroleum ether at a dose of 200 and 400 mg/kg were tested for laxative activity, whereas agar-agar 300 mg/kg, p.o. was used as standard drugs. Among all the extract, the petroleum ether extract was found to possess the most effective laxative activity. Therefore, Anethum graveolens fruits can be a substitute for synthetic laxative drugs having adverse...
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Posted by admin on Apr 12, 2018 in |
Introduction: Samasarkara churna is the Ayurvedic medication preferred treatment of dyspepsia, loss of appetite and piles, formulated by mixing powder of cardamoms, long piper, black piper, flowers of Mesua ferrea, cinnamon and Sugar. Method: With the help of reported composition and standard procedure, formulated Samasarkara churna was compared with the market formulation. Efforts have been made to developed quality control parameters of Ayurvedic formulation Samasarkara churna by observing of organoleptic features, microscopical characters, and physicochemical properties. Results: Ash values and volatile oil content of standard and test sample were found to be 4.75, 2.25 and 0.2% w/v and 0.3% w/v respectively. Crude fiber content, pH of 1% w/v solution of churna and loss on drying were found to be (0.11, 0.34), (6.24, 6.29) and (0.7, 0.8) respectively. Calculated extractive values confirm that water-soluble contents are more in the Samasarkara churna. Discussion: After analyzing samples of Samasarkara churna by different parameters such as total ash, water, and alcohol soluble extractive values, lipid and volatile oil content, microscopic and phytochemical investigation...
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