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SYNTHESIS AND BIOLOGICAL EVALUATION OF CYCLOPROPANE DERIVATIVE OF COMBRETASTATIN CA-4-PHOSPHATE
Combretastatin A-4 (CA-4) is an anti-mitotic agent that is gaining rapid recognition among cancer biologists and clinicians as one of the newer vascular disrupting agents, (VDAs) for cancer therapy. CA-4 belongs to a group of tubulin binding natural products called combretastatin, derived from the African Bush Willow, Combretum caffrum. Due to CA-4's in-vivo efficacy, several analogs of CA-4 have ...
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COMPARATIVE STUDY OF IN VITRO ANTHELMINTIC ACTIVITY OF SAP OF AZADIRACHTA INDICA (NEEM)
The present study was designed to judge the in vitro anthelmintic activity of sap of Azadirachta indica. The duct roundworm, Pheretima posthuma, has been reported to cause severe health issues in immeasurable folks round the world. Records prove that a lot of the liquid extracts obtained from varied elements of various seasonal plants exhibited significant anthelmintic activity against Pheretima p...
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ANTIBACTERIAL AND ANTIOXOIDANT PROPERTIES OF SILK FABRIC DYED WITH CICHORIUM INTYBUS ROOT EXTRACT
The present study was conducted to investigate the color strength (K/S), colorfastness, antibacterial and antioxidant properties of silk using fabric Cichorium intybus root extract as a natural dye. Comparative results of color fastness (fastness to wash, rub, light and perspiration) and colorimetric properties (CIELab and K/S values) of dyed silk samples were studied to quantify the effect of mor...
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PROTECTION OF HIPPOCAMPAL AND ISLET BETA CELLS IN VITRO BY EMODIN FROM LEAVES OF RUMEX CONFERTUS
The natural anthracene derivative emodin (1,3,8-trihydroxy-6-methylanthraquinone) is known as an anticancer agent. In the present work, it was isolated for the first time from the ethanol extract of Rumex confertus leaves, widely used in Armenia as a vegetable. It was purified in two-step low-pressure liquid chromatography – a significantly easier and inexpensive procedure compared with those us...
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PHYTOCHEMICAL CHARACTERIZATION AND CYTOTOXIC EVALUATION OF METHANOLIC EXTRACT OF GARCINIA INDICA FRUIT RIND
Natural products from plants are rich sources of chemical diversity and most of the pharmacologically active principles currently used as drugs, including anticancer agents are plant products. The present study aims at phytochemical screening and evaluation of the anticancer potential of methanolic extract of Garcinia indica fruit rinds belonging to Family Clusiaceae. The methanolic extract of dri...
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ISOLATION OF SULFATED POLYSACCHARIDES FROM GREEN ALGAE ENTEROMORPHA INTESTINALIS AND ITS EFFECT ON THE GROWTH OF HEPATOCARCINOMA CELL LINE
Identification of natural marine bioactive molecules and their therapeutic potential is valuable considering that there are reduced chances of undesirable side effects. This study was designed to isolate and purify the polysaccharides from E. intestinalis and evaluate its anti-cancer effect on human hepatocarcinoma cell lines (Hep3B). Polysaccharides from Enteromorpha intestinalis were isolated an...
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NATURAL REMEDIES TARGET DIFFERENT THERAPEUTIC PATHWAYS IN ORAL MUCOSITIS INDUCED BY CANCER CHEMO OR RADIOTHERAPY
Oral mucositis (OM) is an inflammatory condition affecting oral mucosa. The etiology of this type of inflammation is associated with exposure to radiotherapy or chemotherapeutic drugs. Herbal drugs have been used to induce healing of different types of gastrointestinal ulcers. The role of medicinal plant in cancer therapy-induced oral mucositis has been investigated extensively. Preclinical studie...
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HEPATOPROTECTIVE ACTIVITY OF UVARIA NARUM IN PARACETAMOL-INDUCED HEPATIC DAMAGE IN RATS: A BIOCHEMICAL AND HISTOPATHOLOGICAL EVALUATION
Uvaria narum Wall (Annonaceae) is described as a hepatoprotective in Ayurveda, the Indian system of medicine. However, there are no scientific reports in the modern literature regarding its usefulness as a hepatoprotective agent. The present study was carried out to evaluate the hepatoprotective activity of alcoholic (UNAL) and aqueous (UNAQ) extracts of leaves of Uvaria narum Wall in paracetamol-...
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GC-MS ANALYSIS OF THE METHYLENE CHLORIDE AND n-BUTANOL FRACTIONS OF THE METHANOLIC EXTRACT OF ANTIGONON LEPTOPUS (HOOK & ARN.)
Antigonon leptopus Hook & Arn. (family Polygonaceae), also called: chain of love, Queen’s wreath and Mexican creeper is a fast-growing vine with stems reaching up to 20 feet long. It has heart-shaped, green leaves climbing by tendrils which wrap around many types of supports. It is native to Mexico and commonly found in tropical Asia, Africa, the Caribbean, and the Americas. It possesses ant...
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COMPARATIVE PHYSICO CHEMICAL ANALYSIS OF VYOSHADIVATI– AN AYURVEDIC POLYHERBAL FORMULATION W.S.R TO MARKET SAMPLES
The quality control assessment of herbal formulations is of great significance to justify their acceptability in the modern system of medicine though the drug may be therapeutically potent. Ayurvedic formulations prepared by several manufacturers are guaranteed to carry out the quality control test as per the standards mentioned in the Ayurvedic Formulary of India. Though the standards have been f...
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