Posted by admin on Sep 30, 2021 in |
Objective: To investigate the Pharmacognostic and in-vitro Antioxidant, Anti-inflammatory & Anti-diabetic Activity of the flower of the Himalayan Rhododendron Arboreum. Methods: The collected plant flowers of Rhododendron Arboreum were cleaned with distilled water and air-dried at room temperature under shade (25-27 °C) and reduced to the appropriate size of the powder. The powdered plant materials are further extracted by cold maceration with hydroalcoholic as well as the aqueous solvent. The filtrates obtained from the successive maceration were concentrated under reduced pressure using a rotary evaporator followed by hot air set at 40 °C. The dry extract obtained was harvested, and the dried extract was transferred into airtight bottles and stored in a refrigerator at -4 °C. The powdered flowers of Rhododendron Arboreum and hydroalcoholic and aqueous extract were standardized via pharmacognostic parameters. Phytochemical screening of Hydro-alcoholic and aqueous extract of Rhododendron Arboreum revealed the presence of tannins, flavonoids, phenol, triterpenes, Steroids & carbohydrates. Different flowers extract of Rhododendron Arboreum accessed for in vitro antioxidant potential by using the DPPH...
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Posted by admin on Sep 30, 2021 in |
Indole-3-carbinol, a phytoactive constituent obtained from cruciferous vegetables like Brussels, sprouts, cabbage and cauliflower. It has chemopreventive properties supported by numerous studies carried out to prevent breast, lung, prostate, leukemia and ovarian cancer. Indole-3-carbinol possesses therapeutic benefits like antimicrobial, neuroprotective and antitumor properties. However, it has got poor oral bioavailability due to limitations like metabolic instability in acidic media, thermal instability, etc. The review focuses on the chemistry, anticancer mechanism, limitations, bioavailability, pharmacokinetics, and toxicities studies related to I3C. It also focuses on analytical methods and current approaches for developing an improved delivery system for Indole 3 carbinol by overcoming bioavailability and toxicity limitations. I3C has reported showing limited efficacy in clinical trials due to its poor oral bioavailability. Hence administration of I3C from alternative routes is explored by formulating it as nanoparticles, nanocapsules, suspensions, microemulsions,...
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Posted by admin on Aug 31, 2021 in |
Herbal medicines are widely used since time immemorial indicating that herbs are a growing part of modern, high-tech medicine. Current advancement in drug discovery technology and search for novel chemical diversity have intensified the efforts for exploring lead from “Ayurveda” the traditional system of medicine in India. Achyranthes aspera Linn. (Amaranthaceae) has been important coniferous plant in ayurvedic and indigenous medicinal systems. The medicinal plants are used for treatment of various diseases because of their safety and effectiveness. The problem of microbial resistance is growing and the outlook for the use of anti-microbial drugs in the future is still uncertain. The Clinical trials and animal research support the use of Achyranthes aspera for anti-inflammatory, anti-malarial, anti-ulcer genic, treatment of emotional stress and trauma, anti-microbial, insecticidal, fungicidal, asthma. Though almost all of its parts are used in traditional systems of medicines, seeds, roots and shoots are the most important parts which are used medicinally. The present review describes some of the important medicinal properties of Achyranthes aspera, which are instrumental...
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Posted by admin on Aug 31, 2021 in |
Natural plant products have been used throughout human history for many purposes. Dalbergia sissoo is also an herbal medicinal plant that belongs to the family Fabaceae (Leguminosae). Therefore, the aim of the present review is an effort to give a detailed survey of the literature on its traditionally medicinal use, morphology, phytochemistry, and pharmacological activities of the plant Dalbergia sissoo. Dalbergia sissoo is traditionally used to treat various systemic diseases and disorders such as cardiac diseases, gastrointestinal related disorders and diseases, sexual diseases, and skin diseases. It contains many active constituents, i.e., flavonoids, alkaloids, glycosides, carbohydrates, tannins proteins, fatty acids, and amino acids, useful in treating various types of diseases. Plant part extracts from Dalbergia sissoo are reported on anti-inflammatory, anti-termite, anti-diabetic, analgesic and antipyretic, anti-helminthic, antioxidant, antimicrobial, antinociceptive, osteogenic, anti-spermatogenic, gastroprotective, neuroprotective, anti-molluscicidal, anti-larvicidal, antiulcer, immunomodulatory, antibacterial activity are revealed in this review...
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Posted by admin on Aug 31, 2021 in |
Tinospora cordifolia (Gulvel) is traditionally used in ayurvedic medicine for apparently much varied conditions. It is commonly used in combination with other substances or sometimes alone. Supportive evidence from pharmacological studies suggests its prominent role in immune-modulation in conditions like diabetes mellitus, obstructive jaundice, and hepatic and splenic injury. Antioxidant, radioprotective, antihyperglycemic, anti-inflammatory, antiulcer and antispasmodic properties and capacity to dissolve urinary calculi also have supportive evidence. It is a potential antidepressant and enhances cognition and memory. Immune- modulation, preventing oxidative damage, and relieving inflammation are likely explanations for benefits in infections, joint inflammation, and allergies. The constellation of various activities plays a role in its protective effects against antitubercular and cytotoxic drugs, and toxins. It is helpful in potentiating other substances in the form of simple extraction. This review discusses its formulations, the relevance of supportive evidence and possible mechanisms of actions for its claimed benefits, and future...
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