INDOLE-3-CARBINOL: A REVIEW ON CURRENTTRENDS AND FUTURE PROSPECTSAbstract
Indole-3-carbinol, a phytoactive constituent obtained from cruciferous vegetables like Brussels, sprouts, cabbage and cauliflower. It has chemopreventive properties supported by numerous studies carried out to prevent breast, lung, prostate, leukemia and ovarian cancer. Indole-3-carbinol possesses therapeutic benefits like antimicrobial, neuroprotective and antitumor properties. However, it has got poor oral bioavailability due to limitations like metabolic instability in acidic media, thermal instability, etc. The review focuses on the chemistry, anticancer mechanism, limitations, bioavailability, pharmacokinetics, and toxicities studies related to I3C. It also focuses on analytical methods and current approaches for developing an improved delivery system for Indole 3 carbinol by overcoming bioavailability and toxicity limitations. I3C has reported showing limited efficacy in clinical trials due to its poor oral bioavailability. Hence administration of I3C from alternative routes is explored by formulating it as nanoparticles, nanocapsules, suspensions, microemulsions, liposome.
Tisha Pandav and Ashwin Mali *
Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Erandawane, Pune, Maharashtra, India.
28 June 2021
16 September 2021
19 September 2021
30 September 2021