Posted by admin on Dec 31, 2021 in |
Background: The most common disease of endocrine disorder is diabetes due to underlying causes and pathophysiologies. It is spreading swiftly worldwide and is expected to reach up to 4.4% in the world by 2030. There are numerous synthetic glucose-lowering drugs on the market, but they all have detrimental effects. As a result, this necessitates the search for an alternative anti-diabetic agent from a natural source, i.e., herbal remedies that have been used traditionally and have a safe profile. Aim of the study: The purpose of this study was to look into the anti-diabetic activity of C. cuspidatus methanolic leaves extract on the glycation of Bovine Serum Albumin by measuring fluorescence intensity at various concentrations (1 mg/ml, 2 mg/ml, 4 mg/ml, 6 mg/ml, 8 mg/ml, 10 mg/ml) using positive control 1mM of Aminoguanidine (1 mg/ml, 2 mg/ml, 4 mg/ml, 6 mg/ml, 8 mg/ml, 10 mg/ml). Methodology: Phytochemical screening of Chamaecostus cuspidatus for determination of Phytoconstituents. BSA- Glucose Assay for in-vitro Glycation- methodology (Brownlee et al., 2013). BSA (l0 mg/mL) was...
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Posted by admin on Dec 31, 2021 in |
Essential oils are largely employed for their therapeutic properties, being marketed extensively in pharmaceutical and cosmetic industry. Lavender oil is known for its excellent aroma. Therefore, it is extensively used in the cosmetic, perfumery, and flavour industries. The lavender oil is known to possess sedative, carminative, antidepressive, and anti-inflammatory properties. The aim of our study was to assess the purity and quality of lavender oils, available on the market from various commercial producers. Therefore, essential oil compositions of lavender oil were analyzed using gas chromatography-mass spectrometry (GC-MS). Chromatographic analyses were carried out on HP-5 MS column. The injector volume was 1 µl in split mode (40:1) and the carrier gas was helium at a flow rate of 0.8 ml/min. 33 essential chemical constituents were identified based on GC-MS in lavender oil supplied from an herbalist. The major components of the lavender oil were found linalyl acetate (37.82 %), linalool (33.07 %), eucalyptol (4.88 %), camphor (4.07 %), lavandulol acetate (1.53 %) and caryophyllene (1.43...
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Posted by admin on Dec 31, 2021 in |
The Plant Costus igneus is a member of the Costaceae family. The family Costaceae has about 200 species, of which genus Costus being largest comprises about 104 species. Costus igneus is indigenous to South-East Asia. Costus igneus is often called as ‘Insulin plant’ as it helps to elevate the insulin levels in the body and hence, works as a hypoglycemic agent. The phytochemical analysis of the leaves of Costus igneus revealed that it has higher compositions of iron, protein, and antioxidant substances such as ascorbic acid, α-tocopherol, β-carotene, terpenoids, steroids, and flavonoids. The traditional utilization of this plant included promoting healthy life and age, treating rashes, asthma, and bronchitis, reducing fever and eliminating intestinal worms. This article aims to review the pharmacognostic study of Costus igneus and explore its pharmacological activities such as antidiabetic activity, antiproliferative activity, antimicrobial activity, antiurolithiatic activity, its effects on learning and memory, antioxidant activity, hepatoprotective activity,...
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Posted by admin on Dec 31, 2021 in |
Coronavirus illness 2019 (COVID 19) has wreaked havoc worldwide and resulted in a high number of deaths. One of the key reasons for the coronavirus illness (COVID 19) having such a large impact on society is its unanticipated spread, while it has prevented adequate preparation. While it will take decades to develop a vaccine, immediate interventions are required to prevent COVID 19 related mortality. We have discovered that the immune system is crucial in reducing the severity of COVID 19 and that by modulating it, it’s possible to save people’s lives. Nowadays, post-Covid diseases Mucormycosis also spreads in humans, which is very dangerous to humans financially and mentally. Because any authority has approved no specific treatments or vaccines, there is a need for an alternative to improve population immunity. Antioxidants derived from natural resources can be used as a nutraceutical to boost immunity. The nutraceuticals are non-toxic and can be used by people of all ages. There is a chance that if they include nutraceuticals in their diet regularly,...
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Posted by admin on Nov 30, 2021 in |
Neurodegenerative movement disorder of the central nervous system (CNS) (Parkinson’s disease (PD)) is characterized by necrosis of dopaminergic neurons within the substan tianigra pars compacta are ain the midbrain. The PD cause is still unknown and seems to be multifactorial. Oxidative stress and mitochondrial impairment have been the main consequences, which offer prominent clues regarding the disease mechanisms. The effect of free radicals and oxidative stress on the cascade of events resulting in dopamine cell degeneration in PD has been demonstrated. In-built protective mechanisms, including enzymatic and non-enzymatic antioxidants within the CNS, effectively prevent neuronal cell loss because of free radicals. However, aging is associated with a decrease in the production of these antioxidants. Thus, antioxidant therapy alone or combined with available treatment methods offers an attractive method to treat or prevent neurodegeneration in PD. We summarized the recent discoveries of potential antioxidant agents to modulate free radical-mediated oxidative stress resulting in neurotoxicity in...
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