Posted by admin on Jun 30, 2026 in |
Diabetes mellitus is a long -term condition that affects how the body processes glucose, leading to constantly high blood sugar levels due to issues with insulin production and after effects. The widespread incident of diabetes is increasing, and it is associated with owing to sedentary lifestyles, obesity, unhealthy dietary habits, genetic predisposition, and environmental factors. Chronic hyperglycemia contributes to oxidative stress, inflammation, mitochondrial dysfunction, and dysregulation of signaling pathways such as NF-κB, PI3K/Akt, AMPK, MAPK, leading to microvascular and macrovascular complications. Conventional diabetes treatment mainly manages sugar level that might lead to long term challenges such as low blood sugar, stomach problems, harm to organs, weight increase, resistance to drugs, and restricted capability to avoid diabetes-related complications. Plant-based treatments a supportive and targeted approach for managing diabetes. With strong abilities to lower blood sugar, reduce oxidative stress, fight inflammation, and protecting insulin-producing cells and signaling, expand sugar usage by cells, reducing harmful free radicals, and confining inflammation-related substances. Current development in nano-based formulations and technique for delivering plant chemicals...
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Posted by admin on Jun 30, 2026 in |
Hyperglycemia due to insulin secretion or action abnormalities, or both, characterizes diabetes mellitus, a chronic metabolic condition. Using streptozotocin (STZ)-induced diabetic Wistar rats, this research aimed to determine whether or not extract from the leaves of Tinospora cordifolia had any anti-diabetic effects. A single intraperitoneal injection of 55 mg/kg streptozotocin was used to develop diabetes, and for 28 days, the mice were given an oral dosage of 300 mg/kg of an ethanolic extract of Tinospora cordifolia leaves. The gold standard medicine for comparison was glibenclamide (10 mg/kg). Changes in body weight and fasting blood glucose levels were used to evaluate the extract’s anti-diabetic effectiveness. Tannins, flavonoids, and alkaloids were detected in the phytochemical analysis of the extract. In diabetic rats, the extract treatment led to a 58.2% decrease in blood glucose levels (P < 0.01) and an improvement in body weight. The outcomes were similar to those of the gold standard medication, glibenclamide. According to the results, a 50% ethanolic Tinospora cordifolia extract has strong anti-diabetic effects and might...
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Posted by admin on Jun 30, 2026 in |
Oxidative stress caused by free radicals contributes significantly to aging and various chronic diseases, including cardiovascular disorders, cancer, diabetes mellitus, and neurodegenerative conditions. Natural antioxidants from plant sources have gained scientific attention due to their therapeutic potential and safer profile compared to synthetic antioxidants. The present study comparatively evaluated the in-vitro antioxidant activity of Punica granatum peel extract and Vitis vinifera seed extract using phytochemical screening and Ferric Reducing Antioxidant Power (FRAP) assay. Ethanolic extracts of both plant materials were prepared by maceration and subjected to preliminary phytochemical analysis for the detection of phenolics, tannins, and flavonoids. Antioxidant activity was assessed at concentrations ranging from 100–800 µM by measuring absorbance at 593 nm using the FRAP method. Both extracts exhibited concentration-dependent antioxidant activity with increasing absorbance at higher concentrations. However, Punica granatum peel extract consistently showed greater ferric reducing antioxidant power than Vitis vinifera seed extract at all tested concentrations. At 800 µM, the absorbance value of Punica granatum was 0.8, while Vitis vinifera showed 0.3. The superior antioxidant...
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Posted by admin on Jun 30, 2026 in |
Opuntiol is a biologically active flavonol present in Opuntia elatior Mill. (Cactaceae) that exhibits significant pharmacological activities such as antioxidant, anti inflammatory and anticancer effects. Reliable analytical methods are therefore required for its quantitative estimation in plant extracts and pharmaceutical preparations. The present study aimed to develop and validate a rapid, sensitive and reproducible densitometric HPTLC method for the quantification of Opuntiol. Opuntiol was isolated from the fruits of Opuntia elatior using column chromatography and its purity was confirmed by TLC and UV spectroscopy. Chromatographic separation was achieved on silica gel 60 F254 plates using an optimized mobile phase consisting of ethyl acetate:water:formic acid:glacial acetic acid:n-hexane (7:1:1.1:1.1:5 v/v). Densitometric scanning was performed at 280 nm. Densitometric scanning was yielding a well-resolved band with an Rf value of 0.42 ± 0.005. The method showed excellent linearity in the range of 10–120 ng/spot with a correlation coefficient of 0.997. The limits of detection and quantification were 8.13 ng/spot and 24.65 ng/spot, respectively. Precision studies demonstrated %RSD values below 2%, confirming good...
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Posted by admin on Jun 30, 2026 in |
The evolution of helminthes drug resistance and the increased expense of traditional medications have spurred investigation into medicinal plants as potential alternatives to anthelmintics. Utilizing P. posthuma, the present study focuses on the anthelmintic activity of three traditionally used plants in Bangladesh. Mimosa pudica (family: fabaceae), Terminalia bellirica (family: Combretaceae), Calotropis gigantea (family: Apocynaceae). At all tested concentrations (25, 50 and 100 mg/ml), of the plant extract showed a significant anthelmintic effect. The highest activity or effectiveness was observed at 100 mg/ml. At these maximum concentrations, Calotropis gigantea showed the most potent anthelmintic effect among the plants, achieving paralysis in 19 ±5 minutes and death time in 86 ± minutes. This was succeeded by Terminalia bellirica (paralysis at 43 ±5min and death at 185±5 minutes) and Mimosa pudica (paralysis at 58 ± 5 minutes and death at 229 ±5 minutes). This result supports the traditional use of these plant-based anthelmintic...
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