Posted by admin on Jun 30, 2026 in |
In pursuit of anticancer metabolites from natural sources, we examined organic extracts of Solanum incanum berries collected in Oman. The ethyl acetate fraction demonstrated significant inhibition of Carbonic Anhydrase (CA) activity, with an IC₅₀ value of 20.20 ± 1.2 µg/ml. From this fraction, a β-sitosterol derivative was isolated and shown to suppress the proliferation of MCF-7 breast cancer cells by 71.5% in the MTT assay. These findings suggest that S. incanum represents a promising source of potential anticancer...
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Posted by admin on Jun 30, 2026 in |
Swietenia macrophylla King, widely recognized as big-leaf mahogany or sky fruit, is a highly prized tropical hardwood species belonging to the Meliaceae family traditionally used for managing diabetes, hypertension, inflammation, and various other ailments. Despite growing research interest, existing studies remain fragmented, largely limited to in vitro and acute animal models, with significant variability in extract preparation and scarce standardized clinical data. This review systematically compiles, organizes, and critically analyzes the botanical description, taxonomic classification, ethnomedicinal uses, major bioactive compounds, broad spectrum of pharmacological activities, toxicity and safety analysis of Swietenia macrophylla. The plant is notably high in limonoids like swietenine, swietenolide, and various derivatives, which contribute to its significant pharmacological potential, including antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, anti-aging, wound healing, and other effects. Pharmacological studies have demonstrated significant bioactivities through multiple mechanisms, notably modulation of Nrf2, NLRP3 inflammasome, PPARγ activation and related pathways. The present work offers a consolidated and up-to-date framework that addresses research gaps, variability in extract efficacy, and the need for further clinical validation, thereby...
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Posted by admin on Jun 30, 2025 in |
Chocolate is the most loving food among the people. It is the easiest form to chew and absorb for every individual. This research deals into the Innovative application of herbal chocolates, a delightful fusion of traditional enjoyment and holistic well-being. The blending of herbal ingredients with the luxurious texture of chocolate has given rise to a new category of confectionery that not only satisfies sweet cravings but also offers potential health advantages. The essential target of this study was to formulate and evaluate nutritious chocolate and nutritional supplement containing anti arthritis property. Chocolate is a range of products derived from cocoa (cocoa) mixed with fat and finely powered coconut sugar to produce a solid confectionery. Sesame is the herbal drug which has several medicinal properties, like anti arthritis property, antioxidant property, from the prevention of rheumatoid arthritis. Sesame was used to improve blood pressure and act as anti aging agent. Thus, we have to formulate the chocolate with aqueous extract of sesame. Chocolate is a sophisticated and infinitely adaptable...
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Posted by admin on Jun 30, 2025 in |
Diabetes mellitus is a globally prevalent chronic metabolic disorder characterized by hyperglycemia due to insufficient insulin production or impaired insulin utilization. It is associated with various acute and chronic complications, including neuropathy, nephropathy, retinopathy, and cardiovascular diseases. With rising incidence rates, especially in urban regions of developing countries like India, diabetes poses a major public health challenge. While conventional treatments involve insulin therapy and oral hypoglycemics, herbal medicine offers a promising complementary approach. This study reviews the antidiabetic potential of several medicinal plants, such as Momordica charantia, Aloe barbadensis, Catharanthus roseus, Glycyrrhiza glabra, Syzygium cumini, Curcuma longa, Stevia rebaudiana, Senna auriculata, Cinnamomum cassia, and Taraxacum officinale. Each plant is explored for its phytoconstituents, such as alkaloids, flavonoids, glycosides, and terpenoids, which exhibit hypoglycemic, antioxidant, anti-inflammatory, and insulin-mimetic properties. Experimental evidence from in-vivo and in-vitro studies supports their efficacy in managing blood glucose levels, improving insulin sensitivity, and protecting pancreatic β-cells. This compilation emphasizes the therapeutic potential of herbal remedies as safe and cost-effective adjuncts in diabetes management and encourages...
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Posted by admin on Jun 30, 2025 in |
Sickle cell disease (SCD) treatment and management remain a challenging puzzle, especially among developing Nations. We evaluated catechin’s sickling-suppressive properties using in-vitro and bioinformatics approaches in human sickle erythrocytes. Sickling was maximally induced (76%) using 2% sodium metabisulfite (SMS) at 3h. Addition of catechin prevented the sickling by SMS at 1mM (81.19%) and reversed the same at 1mM (84.63%), with IC50 values of 1.026µM and 1.103µM, respectively. Based on functional chemistry, catechin alters the functional groups of certain notable compounds within erythrocytes, favouring its anti-sickling effects, as indicated by the observed bends and shifts. From GC-MS and LC-MS analyses, it was observed that catechin treatment favours fatty acid alkyl monoesters (FAMEs) production with concomitant shutting down effects on selenocompound metabolism. Pathway enrichment and topology analyses revealed activation of fatty acid biosynthesis, linoleic acid metabolism and steroid hormone biosynthesis pathways upon catechin treatment. Thus, sickling-suppressive effects of catechin could potentially be associated with modulation of oxygenated and deoxygenated haemoglobin via alteration of human sickle erythrocytes’ functional chemistry and metabolic pathways...
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