EVALUATION OF THE ANTI-DIABETIC EFFECTS OF TINOSPORA CORDIFOLIA LEAF EXTRACT ON DIABETIC RATS INDUCED BY STREPTOZOTOCIN
AbstractHyperglycemia due to insulin secretion or action abnormalities, or both, characterizes diabetes mellitus, a chronic metabolic condition. Using streptozotocin (STZ)-induced diabetic Wistar rats, this research aimed to determine whether or not extract from the leaves of Tinospora cordifolia had any anti-diabetic effects. A single intraperitoneal injection of 55 mg/kg streptozotocin was used to develop diabetes, and for 28 days, the mice were given an oral dosage of 300 mg/kg of an ethanolic extract of Tinospora cordifolia leaves. The gold standard medicine for comparison was glibenclamide (10 mg/kg). Changes in body weight and fasting blood glucose levels were used to evaluate the extract’s anti-diabetic effectiveness. Tannins, flavonoids, and alkaloids were detected in the phytochemical analysis of the extract. In diabetic rats, the extract treatment led to a 58.2% decrease in blood glucose levels (P < 0.01) and an improvement in body weight. The outcomes were similar to those of the gold standard medication, glibenclamide. According to the results, a 50% ethanolic Tinospora cordifolia extract has strong anti-diabetic effects and might be used as a non-invasive treatment for diabetes.
Article Information
7
683-687
655 KB
3
English
IJP
Neelam Pavan Teja *, Darsi Eswar Tony and Nadendla Ramarao
Department of Pharmacology, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur, Andhra Pradesh, India.
neelampavanteja6@gmail.com
26 May 2026
23 June 2026
29 June 2026
10.13040/IJPSR.0975-8232.IJP.13(7).683-87
01 July 2026
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