Posted by admin on Nov 1, 2014 in |
In folk medicine, Aloe camperi, Aloe percrassa (Aloeceae), and Senna singueana L. (Fabaceae) are used in the management of infectious and inflammation-related disorders. The objective of this work was to evaluate the in-vitro hyaluronidase inhibition activities of extracts from these three medicinal plants. Various concentrations (10, 50, and 100 µg/ml) of leaf latex from the two Aloe sp and hydro alcoholic extract of S. singueana leaves were screened using hyaluronidase inhibition assay. The results showed that all the three extracts displayed concentration-dependent inhibitory activities with IC50 values of 771.78, 664.47 and 630.83 μg/ml for A. camperi, A. Percrassa and S. singueana, respectively. Indomethacin, used as a standard drug in this study, showed IC50 value of 27.95μg/ml. Hyaluronidase hydrolyzes hyaluronic acid in the extracellular matrix during tissue remodeling. Since, oligomers from hyaluronic acid degradation are associated with induction of inflammation and hyaluronidase activity up-regulation occurs in chronic inflammatory conditions, hyaluronidase inhibitors are suggested to have a beneficial role in prevention and treatment of inflammation-related disorders. Thus, the hyaluronidase enzyme inhibition...
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Posted by admin on Oct 1, 2014 in |
Rheumatoid arthritis is a chronic immuno-inflammatory systemic disease, affecting 1-2% population worldwide. The disease is very common among women rather men. Mostly the victims of this disease belong to the age group 45 onwards, while juvenile cases are also reported. The exact pathogenesis of the disease is still a question. Reactive oxygen species have been implicated as mediators of tissue damage in arthritic patients. Various herbal plant preparations are reported to scavenge free radicals and improve different human diseases such as diabetes, Alzheimer’s disease, atherosclerosis, etc. The present investigation was designed to evaluate the effectiveness of Nyctanthes arbortristis towards disturbed antioxidant status in inflamed tissue. Nyctanthes arbortristis has been known for medicinal uses such as anti-helmenthic, anti-bacterial activity, etc. Water-soluble ethanolic extract of Nyctanthes seed (NSE) and leaf (NLE) was administered orally to adjuvant-induced arthritic mice (AIA) at the dose of 23.72 mg/kg body weight for 47 days. Enzymatic and non-enzymatic anti-oxidants were assessed on day 2, 14 and 47. On the one hand, daily administration of NLE significantly...
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Posted by admin on Oct 1, 2014 in |
Introduction: Obesity is associated with DM Type-II. The major basis for the association between these two is the ability of obesity to engender insulin resistance. Insulin resistance is a fundamental aspect of etiology of DM Type-II. Different factors increase insulin resistance, but FFA is the most common factor to increase insulin resistance. Aims and Objectives: Most of the obese person (80%) is DM Type-II, but all obese are not diabetic, why? To study the FFA level in obese without DM Type-II verses obese with DM Type-II subjects. Materials and Methods: Subjects were taken from OPD & IPD, Department of Medicine, SRMS, IMS Bareilly (U.P.) India, of both sexes, coming from reasonable distances around Bareilly city. They were from the lower and middle class of rural area having moderate physical activities, with vegetarian as well as non-vegetarian dietary habits and were obese as per new Asian BMI guidelines and have symptoms of diabetes. Subjects were not on any drug treatment before taken blood sample. Serum FFA level estimated by ELISA...
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Posted by admin on Oct 1, 2014 in |
In the present study the anti-inflammatory, analgesic activity and mechanistic pathway of Centratherum anthelminticum (Willd.) Kuntze (CA), Cissus quadrangularis Linn. (CQ) and Kigelia pinnata DC (KP) was tested in rats using carrageenan induced paw edema method. The central analgesic activity was assessed by radiant heat method, hot plate method, and tail immersion method. The peripheral analgesic action was estimated using acetic acid induced writhing test. To establish the mechanism of action of the hydroalcoholic extract, membrane stabilization, antioxidant, antihistaminic, muscle strength, and coordination activity were performed. In anti-inflammatory activity; CA, CQ, and KP showed maximum inhibition of 77%, 70% and 50% respectively. In analgesic activity, CA and CQ treated animals responded propitiously to both central and peripheral analgesia, but KP treated animals demonstrated significant activity only for peripheral analgesia. This can be attributed to membrane stabilization, anti-oxidant, and antihistaminic potential. All the three test drugs have shown both anti-inflammatory activity and analgesic activity with varying potency and mechanisms of...
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Posted by admin on Oct 1, 2014 in |
An ethnomedicinal survey was carried out during August 2008 to October 2008 among tribal medicinal practitioners of the Murong tribes. Various Murong tribal practitioners practiced in their localities for treating different kinds of disease of Ramgarh Upazila, Khagrachari districts of Chittagong Hill Tracts Region in Bangladesh. We observed to use 40 plants species belonging to 29 families in the various treatment of disease. This diversity only adds to the uniqueness of the traditional medicinal practices and opens up scientific possibilities of discovering different drugs from different medicinal plants to treat any given ailment. These tribal medicinal plants were mostly used for the treatment of constipation, cough, fever, diarrhoea, dysentery, diuretic, diabetes, eczema, itches, jaundice, skin disease, vomiting, wound, joint pain and worm. The plants were collected and identified botanically along with their scientific name, local name, family name, habit, parts used and medicinal uses. This detailed information will be helpful for the pharmacognosist, botanist and pharmacologist for the collection and identification of the plant for their research...
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