Posted by admin on Feb 1, 2014 in |
A series of substituted acetophenones are condensed with hydrazides to the corresponding hydrazones which are subsequently cyclized by using volumizer-Haack reaction to give new pyrazole derivatives. All the compounds 4a, 4b, 4c, 4d, 4e were screened for antioxidant, anti-inflammatory activity. Few of the compounds showing good antioxidant and anti-inflammatory...
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Posted by admin on Feb 1, 2014 in |
Adhataoda vasica and Ailanthus excelsa are distributed throughout tropical and subtropical parts of India. Their leaves are used as expectorant and bronchodilator. The present investigation deals with the comparative pharmacognostical study of the leaves of the two species and establishment of its quality parameters. Detailed morphological and qualitative as well as the quantitative microscopic study was carried out. Phytochemical screening of the species followed this. Leaf surface microscopy of Adhataoda vasica shows polygonal thin walled epidermal cells and diacytic stomata whereas Ailanthus excels shows penta and hexagonal epidermal cells and anomocytic stomata. The chief powder characteristics of Adhataoda vasica leaf powder are 2-4 celled blunt covering trichomes, sessile-glandular trichomes, acicular and prismatic calcium oxalate crystals whereas Ailanthus excelsa leaf powder shows multicellular bent thick walled covering trichomes, multicellular head and stalk glandular trichomes, cluster and rosette calcium oxalate crystals. The present work can serve as a useful tool in the identification, authentication, and standardization of the plant material and distinguishing the two species from each other. The present study...
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Posted by admin on Jan 1, 2014 in |
Studies on anticancer and protein inhibition process play a vital role in regulating the cellular process of life and diseases. The present studies have been conducted on ethanolic tuber extract from Globba bulbifera for protease inhibition and breast cancer inhibition. The extract has shown good inhibition for Trypsin, Chymotrypsin and protease K. The extract has also shown MCF-7 (Breast Cancer) inhibition, IC50 value at 235 μg/ml. The inhibition is less compared to the standard compound, tamoxifen (IC50: 37 μg/ml). Hence the present studies have shown good protease inhibition and anticancer (breast cancer)...
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Posted by admin on Jan 1, 2014 in |
Marine macroalgae Sargassum is commonly referred to as brown seaweeds. Commercially and continuously the pharmaceuticals industries are rapidly growing because always demand for new drug discovery is encouraged. Since, brown seaweeds have ample source of bioactive compounds of primary or secondary metabolites. These potential bioactive compounds interest to improve the pharmaceuticals industry. This present study was investigated to explore the antibacterial and antifungal activity of the organic solvents of the brown seaweed Sargassum. Phytochemical analysis of Brown seaweeds of Sargassum longifollium with six different organic solvents was analyzed. All the solvents like Dimethyl Sulfoxide (DMSO), Benzene, Acetic acid, hexane, Di Ethyl ether, and Chloroform has the extraction of phytochemical constituents. Among the six solvents, Dimethyl Sulfoxide (DMSO) extract showed a maximum number of phytochemical constituents and antibacterial and antifungal activity when compared to other five solvent extracts. FTIR identified the responsible functional groups in the solvent extract. These results statements be a necessary (or) recommended that the species of brown seaweeds (Sargassum longifolium) having a potential capacity as a...
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Posted by admin on Jan 1, 2014 in |
Our ecosystem is laden with hazardous and non-hazardous wastes that pose a serious threat to bio-existence. Most pharmaceutical formulations contain chemically-synthesized surfactants. The purpose of this work is to suggest an alternative source of surfactant which would also aid in ridding our environment of harmful wastes. Bacillus licheniformis B-4 strain isolated from a hydrocarbon dump site produces biosurfactant with excellent interfacial properties utilizing unconventional substrates (kerosene and diesel) as carbon sources, and glucose as an energy source. Acid precipitation and foam separation methods were used for biosurfactant recovery and its physicochemical properties evaluated which include the effect of the biosurfactant on the surface tension of water, critical micelle concentration (CMC), emulsification stability (ES) of kerosene and diesel, emulsification index, hemolytic activity, and antimicrobial activity. The results showed that the biosurfactant reduced the surface tension of water from 70.2 to 14.7 Nm-1, CMC was estimated to be 50 mg/l, emulsification stability of kerosene and diesel were obtained as 0.06 and 0.02 min-1, while the emulsification indices were 72.2 and 50...
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