Posted by admin on Dec 11, 2015 in |
Aim: The objective of this study was to evaluate the effect of Commiphora mukul on psoriasis. Materials and Methods: Six female Balb/C mice per group of which, the first three groups served as untreated, disease controls and standard (0.1% dexamethasone) respectively. Animals of groups 4, 5 and 6 were applied 0.5, 1 and 2% of the C. mukul extract on both the ears, respectively. Dermatitis was induced in mice by the application of oxazolone 1.5% (100 µL in ethanol) to the abdominal region for six days. Starting seven days following sensitization, 20 µL of oxazolone 1% in a mixture of acetone and olive oil (4:1) was applied to both sides of the mouse ear on days 7, 10, 13 and 16. For detailed time-course analysis of swelling ear reactions, ear thickness was measured before the sensitization phase (day 7) and after each elicitation on days 10, 13, 16 and 19. Results: C. mukul potently suppressed ear swelling at each time-point. The suppressive rates of C. mukul at concentrations of...
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Posted by admin on Dec 11, 2015 in |
Siddha system is one of the oldest and most ancient traditional prevailing medicinal systems in India especially in our south India. In our system, first preference is given for plant-based medicine. Plant-derived drugs have been a part of the evolution of human health care for thousands of years in India. Elathi kuligai is prepared as per classical Siddha textbook for the respiratory problem in the pediatric age group. It is a poly herbal drug preparation. Before conducting a clinical trial, the preclinical study should be undergone as per WHO guidelines. The present preclinical study aim is to carry out the safety and toxicity of Elathi kuligai . Male and female Wistar rats of age 6 – 8 weeks old. Weighing 220–240 gm was used for this study. Acute and Sub-acute toxicity were carried out as per OECD guidelines 423 and 407. Hematological parameters, biochemical parameters, histopathological study were performed for all animals. The study concludes that on oral administration of dose level of 200mg/kg and 400 mg/kg of body...
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Posted by admin on Dec 11, 2015 in |
Herbals are playing a major role in Siddha system of medicine. Herbals contain plant materials as their pharmacologically active components. The aim of the study is to evaluate the acute and sub-acute toxicity of the Siddha herbal preparation Lagu Seena Chooranam (LSC) for the treatment of Scabies in the pediatric age group. For acute studies, different doses of LSC were administered orally to rats once daily for one week. For sub-acute studies, different doses were administered orally to rats once daily for 28 days in various doses at 200, 400 mg/kg of body weight. Detailed hematological, biochemical, necropsy and histopathological evaluation of organs were performed for all animals. Histopathological analysis revealed that spleen, testes, pancreas, lung, liver, brain, heart, stomach, intestine, bone, ovary, and kidney tissues of treated groups did not show any signs of toxicity. No destruction in hepatic, renal, hemopoietic functions was observed throughout the...
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Posted by admin on Oct 21, 2015 in |
In the present study, the photochemistry of fluoroquinolone antibiotic drug-besifloxacin (1) was investigated under mild conditions similar to those encountered in biological systems namely aerobic as well as an anaerobic condition with UV-A light. When besifloxacin (1) was irradiated with a high-pressure mercury lamp under aerobic conditions it afforded 7-(2-Amino-5-oxo-pentylamino)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo- 1, 4 – dihydro-quinoline-3-carboxylic acid as photoproduct (2) and under anaerobic condition it afforded 7-(3-Amino-azepan-1-yl)-1-cyclo propyl-6-fluoro-8-hydroxy-4-oxo-1,4dihydro-quinoline-3-carboxylic acid as photoproduct (3). The formation of photoproduct was explained by the type-I and type II mechanism of...
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Posted by admin on Oct 20, 2015 in |
A survey was conducted to collect information about the effective medicinal plants used by the Traditional healer to treat diabetes. The use of herbal drugs increased worldwide because of the lack of side effects and efficacy. Traditional healing is practicing throughout the world to treat several diseases. Glycemic disease has become a severe issue in India and all over the world. The traditional healer of West Godavari district studied for the use of medicinal plants to treat diabetes. We report 19 species of plants which are active against diabetes and about the scientific studies that have been conducted on...
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