Posted by admin on Sep 29, 2016 in |
The present study was aimed to the investigation of the anthelmintic potential of crude methanolic extract of the leaves of Abrus precatorius Linn. on Indian earth-worm “Pheretima posthum” and “Tubifex tubifex.” Three concentrations (5, 10, 15 mg/ml) of methanolic extract were studied in activity which involved the determination of the time of paralysis (vermifuge) and time of death (vermicidal) of the worms. Piperazine citrate (10 mg/ml) was used as reference standard drug whereas distilled water as the control. Determination of paralysis time and death time of the worms were recorded. The result shows that methanolic extract possesses vermicidal activity and found to be effective as an anthelmintic. Therefore, the anthelmintic activity of the methanolic extract of Abrus precatorius Linn. Leaves have been...
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Posted by admin on Sep 29, 2016 in |
The tribal people depend on plants and plant products for their livelihood, and most of the people still depend on traditional herbal medicine suggested by traditional medicine men or traditional health practitioners (THPs) for their primary health care. In this paper 36 herbal formulations of 59 plant species belonging to 40 families to cure 16 common diseases suggested by 32 traditional health practitioners have been reported from the study area. The main aim of the present work was to give information and documentation of medicinal plants used by the tribals of the study area. The interviews, group discussions collected the ethnomedicinal information and give and take methods with tribal medicine men and traditional health practitioners mainly belonging to Bhil, Garasia, Kathodia and Meena tribes of the study sites. The present study was carried out in the tribal-dominated areas of Rajasthan such as Udaipur, Dungarpur, Banswara, and part of Sirohi and Chittorgarh...
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Posted by admin on Sep 29, 2016 in |
This study was carried out to evaluate the thrombolytic and membrane stabilizing activities of Launaea sarmentosa plants. The crude methanolic extract of L. sarmentosa (whole plants) was investigated for in-vitro thrombolytic and membrane stabilizing activities at five different concentrations of 2, 4, 6, 8 and 10 mg/ml respectively. In the case of thrombolytic study, it was dose-dependently increased (p<0.01), where streptokinase (30,000 I.U.) was used as standard, and distilled water was treated as a negative control. In the in vitro clot lysis assay method, 10 mg/ml concentration most significantly showed 22.57% lysis of clot (p<0.001). Similarly, crude methanolic extract of L. sarmentosa dose-dependently increased the membrane stabilizing activity in comparison to the standard drug, acetylsalicylic acid (0.10 mg/ml; p<0.01). 10 mg/ml of the extract exhibited 12.11% and 20.55% inhibition of hemolysis by both hypotonic solution and heat-induced hemolysis,...
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Posted by admin on Sep 29, 2016 in |
The purpose of the study was to determine the leaves of Andrographis serpyllifolia for anti-diabetic and antihyperlipidemic effects in streptozotocin-induced diabetic rats. The aqueous, alcoholic and hydroalcoholic extracts of Andrographis serpyllifolia were tested for toxicity up to 4000 mg kg-1 as per OECD-425 guidelines. Anti-diabetic activity was assessed by oral glucose tolerance test and streptozotocin-induced model. In oral glucose tolerance test alcoholic and hydroalcoholic extracts exhibited greater activity compared to aqueous extract. Hence the alcoholic and hydroalcoholic extracts were further screened by the streptozotocin-induced model at 75, 150 and 300mg kg-1 for 15 days. The alcoholic and hydroalcoholic extracts effectively lowered serum glucose, triglycerides, cholesterol, low-density lipoproteins, very low-density lipoproteins, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, urea, creatinine, and elevated high-density lipoprotein levels, body weight and liver glycogen levels. The alcoholic and hydroalcoholic extracts elicited dose-dependent effect, and the effect produced at the lower dose was not considerable. Hydroalcoholic extract (300 mg kg-1) elicited greater anti-diabetic and antihyperlipidemic activity compared to alcoholic extract (300 mg...
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Posted by admin on Aug 24, 2016 in |
The present study was undertaken to evaluate antidiabetic and antioxidant activities of Aloe vera (A. vera, Ghee-kuwar; family: Liliaceae) extract against alloxan-induced diabetes in male adult Charles foster rats to scientifically validate its use against diabetes. A. vera extract and a standard drug (glibenclamide) prepared in aqueous gum acacia (2%, w/v) suspension and fed orally to alloxan induced diabetic rats for 30 days. Biochemical parameters in normal, diabetic control, standard (600 µg/kg bw p.o.) and treated (1 g/kg bw p.o.) animals group were determined and compared. Treatment of alloxan-induced diabetic rats with A. vera extract showed a significant reduction (p<0.001) in blood glucose, lipid peroxide and significantly increased (p<0.001) superoxide dismutase, catalase, and protein. Furthermore, the extract (100-200 µg) when tested for its antioxidant activity in-vitro, showed significant (p<0.001) inhibition in the generation of superoxide anions and hydroxyl radicals. The results of the present study demonstrated anti-diabetic and anti-oxidant activities of A. vera extract which could help in the treatment of diabetes and related...
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