THE STUDY EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF JAPANESE PERSIMMON FRUIT ON FORMALIN-INDUCED INFLAMMATION IN THE RATAbstract
Acute and chronic inflammation is the most important issue in the field of health. Also, due to the side effects of synthetic drugs, herbal products are widely used in the control of inflammation. In this study was investigated the effect of a hydro-alcoholic extract of Japanese persimmon fruit on the formalin-induced inflammation in the rat paw. 30 male Wistar rats were divided into 5 groups: negative control, group treatment with 300 mg/kg of aspirin (positive control group) and the group’s treated with 200, 400 and 800 mg/kg hydro-alcoholic extract of persimmon, respectively. The inflammation was established to sub-planter injection of 2.5% formalin in rats. Level of inflammation was measured to plethysmometer in six stages in the rat paw. These results were shown that in the rat’s treated with different concentrations of extract; inflammation was lower than the positive control group (p≤0.05). Also, the compression of between groups’ treatment with the extract was determined that reduction of inflammation was as dose depend manner (p≤0.05). We conclude that Japanese persimmon may be useful for the management of inflammation but need to perform further studies.
A. A. Hemati, A. Arzi, M. Khataminia *, N. S. Karampor, M. dehghan and E. Ebrahimi
Department of Pharmacology and Toxicology, School of Pharmacy, Jundi Shapur University of Medical Sciences, Ahvaz, Iran.
15 October 2015
26 November 2015
29 November 2015
31 January 2016