THROMBOLYTIC AND MEMBRANE STABILIZING ACTIVITIES OF LAUNAEA SARMENTOSAAbstract
This study was carried out to evaluate the thrombolytic and membrane stabilizing activities of Launaea sarmentosa plants. The crude methanolic extract of L. sarmentosa (whole plants) was investigated for in-vitro thrombolytic and membrane stabilizing activities at five different concentrations of 2, 4, 6, 8 and 10 mg/ml respectively. In the case of thrombolytic study, it was dose-dependently increased (p<0.01), where streptokinase (30,000 I.U.) was used as standard, and distilled water was treated as a negative control. In the in vitro clot lysis assay method, 10 mg/ml concentration most significantly showed 22.57% lysis of clot (p<0.001). Similarly, crude methanolic extract of L. sarmentosa dose-dependently increased the membrane stabilizing activity in comparison to the standard drug, acetylsalicylic acid (0.10 mg/ml; p<0.01). 10 mg/ml of the extract exhibited 12.11% and 20.55% inhibition of hemolysis by both hypotonic solution and heat-induced hemolysis, respectively.
M. M. R. Moghal, M. S. Millat, M. S. Hussain and M. R. Islam *
Department of Pharmaceutical Technology, University of Dhaka, Dhaka, Bangladesh.
14 July 2016
16 August 2016
28 August 2016
31 August 2016