ANTI-DIABETIC AND ANTI-OXIDANT PROPERTIES OF ALOE VERA IN ALLOXAN INDUCED DIABETIC RATS
AbstractThe present study was undertaken to evaluate antidiabetic and antioxidant activities of Aloe vera (A. vera, Ghee-kuwar; family: Liliaceae) extract against alloxan-induced diabetes in male adult Charles foster rats to scientifically validate its use against diabetes. A. vera extract and a standard drug (glibenclamide) prepared in aqueous gum acacia (2%, w/v) suspension and fed orally to alloxan induced diabetic rats for 30 days. Biochemical parameters in normal, diabetic control, standard (600 µg/kg bw p.o.) and treated (1 g/kg bw p.o.) animals group were determined and compared. Treatment of alloxan-induced diabetic rats with A. vera extract showed a significant reduction (p<0.001) in blood glucose, lipid peroxide and significantly increased (p<0.001) superoxide dismutase, catalase, and protein. Furthermore, the extract (100-200 µg) when tested for its antioxidant activity in-vitro, showed significant (p<0.001) inhibition in the generation of superoxide anions and hydroxyl radicals. The results of the present study demonstrated anti-diabetic and anti-oxidant activities of A. vera extract which could help in the treatment of diabetes and related complications.
Article Information
5
319-324
515
1036
English
IJP
P. Verma *, V. Kumar, B. Rathore, R. K. Singh and A. A. Mahdi
Department of Biochemistry, Maharani Laxmi Bai Medical College, Kanpur Road, Jhansi, Uttar Pradesh, India
pbmlbc@gmail.com
22 June 2016
18 July 2016
29 July 2016
10.13040/IJPSR.0975-8232.IJP.3(7).319-24
31 July 2016