PHYTOCHEMICAL AND ANTI-CONVULSANT STUDY OF NYCTANTHES ARBOR-TRISTIS EXTRACTAbstract
The drug is obtained from the dried fruit of Nyctanthes arbor-tristis of family Oleaceae. It is also called Coral Jasmine, Parijat, and Harsingar, etc. To confirm the veracity of the claim above, the anticonvulsant effect of the ethanolic extract has been evaluated. In this investigation, the rats were pretreated with different dose of Nyctanthes arbor-tristis ethanolic extract (100, 200 mg/kg) for 14th days and then, they were subjected to maximal electroshock-seizures, the dose of 100 and 200 mg/kg significantly reduced the duration of hind limb extension, and both the doses were statistically found to be equipotent. The reference, standard, Phenytoin (30 mg/kg) provided complete protection. Thus, the present study revealed the anticonvulsant effect of Nyctanthes arbor-tristis against maximal electroshock-induced convulsion in the rat.
S. Pundir * and A. Kumar
Department of Pharmaceutical Sciences, S. D. College of Pharmacy and Vocational Studies, Muzaffarnagar, Uttar Pradesh, India.
21 December 2017
20 January 2018
13 February 2018
01 May 2018