Posted by admin on Jul 31, 2018 in |
An intensive phytochemical study of the two parts of the Piper caldense plant brings the isolation of secondary metabolites, generated by shikimate and the mevalonate pathways. Using chromatographic techniques, the ethanolic extract of leaves afforded two pheophytyns, the pheophytin (1), 151-hydroxy-pophyrinlactone a (2), a mixture of the β-sitosterol and stigmasterol steroids (3-4). Four derivatives of benzoic acid (5-8) and the trilinoein (9) were isolated from the fruits. The spectroscopic methods such as 1H and 13C Nuclear Magnetic Resonance (NMR) and electrospray mass spectrometry (ESI-MS) were used for structural characterization. The compounds were screened for their in-vitro antifungal activity against seven Candida strains. The control used in the antifungal assays was nystatin. In general, three compounds revealed fungal sensitivity, especially, the prenylated benzoic acid derivative (6) which accomplished the lowest minimum inhibitory concentration...
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Posted by admin on Jul 31, 2018 in |
The research in alternative medicine and the need for the plant-based medicines that affect the ‘mind’ is developing day to day. The aim of the present study was to explore Leptadenia reticulata (roots), Mimusops elengi (bark) and Evolvulus alsinoides (Whole plant) using different animal models (conditional avoidance response, hole board test, open field test), anticonvulsant (MES induced convulsions), myorelaxant action (rotarod) and hypnotic property (Phenobarbital-induced sleeping) in suitable animal models. Diazepam (2 mg/kg, p.o), Phenytoin (25 mg/kg, p.o) and Phenobarbital sodium (50 mg/kg, i.p) were used as the standard drugs, and the acetone and ethanolic extract were 200 mg/kg, p.o Selected as per OECD guidelines. Results suggested that the extracts produced significant (p<0.001) anti-anxiety, myorelaxant and hypnotic action, but not significant anticonvulsant effect (p<0.05). Further studies are needed to identify the anxiolytic mechanism(s) and the phytoconstituents responsible for the observed CNS effects of the acetone and ethanolic extract of the selected...
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Posted by admin on Jul 31, 2018 in |
Santalum rubrum is medicinally important plant belonging to the family of Santalaceae. It has been used extensively by Ayurvedic practitioner and is also reported to contain anthraquinones and flavonoids, these constituents are well documented to possess anti-inflammatory activity. The fatty acid compositions of the petroleum ether extract of seeds of this plant were determined by Gas Chromatography-Mass Spectrophotometer. 7 compounds were identified from the extract of seeds (99.97 %), and they are palmitic acid, stearic acid, oleic acid, linoleic acid, arachidonic acid, behenic acid and lignoceric acid of methyl ester. Among all fatty acids of linoleic acid showed the highest concentration...
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Posted by admin on Jul 31, 2018 in |
Purpose: The aim of the present study was to investigate the wound healing activity of the selected Indian medicinal plants Terminalia chebula, Terminalia bellarica, Ficus racemosa, Piper nigrum, Zingiber officinalis. Method: Excision and incision models for diabetes-induced rats at specified varying doses. Result: The plants showed a definite, positive effect on wound healing. Conclusion: The efficacy of these plants in wound healing may be due to its action on antioxidant enzymes, thereby justifying the traditional...
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Posted by admin on Jul 31, 2018 in |
ABSTRACT: Context: Syzygium cumini (L.) Skeels (Myrtaceae) is popularly known to have various pharmacological and traditional uses. Before this study, there were no claims reporting its potential use for dengue by increasing platelet and leukocyte levels. Objectives: The effects of the methanolic extract of S. cumini leaves on the platelet and leukocyte levels were evaluated in Sprague-Dawley rats at doses 400 mg/kg and 800 mg/kg body weight. Methodology: The bioassay utilized 24 rats that were divided into four groups (n = 6) where hydroxyurea was used to induce depletion of platelet and leukocyte levels in all groups. After induction, oral treatment of methanolic extract was given daily to the treatment groups for six days. The platelet and leukocyte counts were measured before induction to get the baseline, after induction, and at the 1st, 3rd, and 6th day of treatment. High-performance liquid chromatography (HPLC) analysis was also conducted to identify the phenolic compounds present in the extract. Results: Results revealed that the methanolic extract of S. cumini caused an increase...
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