Posted by admin on Dec 31, 2020 in |
Objective: The aim of this study was to evaluate the anticancer activity of a series of six structurally related [1, 4]-Benzoquinone monooximes and to investigate structure-activity relationships (SAR) of these compounds. Materials and Method: The mono-oximes obtained by oximination of para-benzoquinones 1-4 had their structures confirmed by ¹H NMR, 13C NMR. The cytotoxic study was assessed by the MTT assay on three tumor cell lines: HL60 (promyelocytic leukemia), NCI-H292 (lung cancer), and MCF-7 (breast adenocarcinoma). Results: Six oximes were synthetized 2 – methyl-[1,4]-benzoquinone oxime tosylate (I), 5-isopropyl-2-mehyl-[1,4]-benzoquinone oxime tosylate (II), 5-isopropyl-5-mehyl-[1,4]-benzoquinone oxime tosylate (III), 5-isopropyl-2-mehyl-[1,4]-benzoquinone oxime (IV), 2,5-dimethyl-[1,4]-benzoquinone oxime tosylate (V), 2-methyl-[1,4]-benzoquinone oxime tosylate (VI). Compounds II to V showed significant activity against all cell lines; while compound I and VI presented low or no activity. Conclusion: These experimental data lead to the conclusion that oximes (II –V) may be used as potential starting structures for the design of novel anticancer...
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Posted by admin on Oct 31, 2020 in |
The main objective of this present work is to evaluate the anthelmintic activity of crude alcohol extracts of the flowers of kachnar (Bauhinia variegata) against Pheretima posthuma as a test worm. The activity was assessed by worm motility assay, which involved the determination of time of paralysis and death of worms. The preliminary phytochemical study of the alcoholic extract was also carried out. The alcoholic extracts exhibited a dose-dependent (25, 50, and 100 mg/ml) inhibition of spontaneous motility and time of death of the worms. The alcoholic extract was found to be effective; the activity was comparable with the standard drug Piperazine citrate and water as a control....
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Posted by admin on Oct 31, 2020 in |
Public interest on herbal drugs increase every passing day in both developed and developing countries. However, its regulations more strict in developed countries than in developing countries. Clarifying the effectiveness and adverse effects of this product is becoming more important. Calendula officinalis and Taraxacum officinale both commonly using in herbal-based therapies due to the speculated antibacterial and anti-cancer effects of them. Several effects of these plants have been associated with their ingredients, such as phytochemicals, flavonoids, essential oils, etc. In this study, we aimed to investigate antibacterial effects and potential anticancer effects of commercial Calendula officinalis and Taraxacum officinale products obtained from herbalist. Antibacterial effects of methanolic extracts of Calendula officinalis and Taraxacum officinale were evaluated via microbroth dilution technique using the Clinical Laboratory Standards Institute (CLSI) recommendations. Anti-cancer effects were evaluated with the MTT cytotoxicity test on the human neuroblastoma cell line (SH-SY5Y). Our results indicate that commercial products show lower antibacterial effects separately and with 1:1 combination that was reported in previous different studies. It has been...
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Posted by admin on Oct 31, 2020 in |
Objective: The main objective of this study is to evaluate the anti-inflammatory activity of hydroethanolic extract of the entire plant except for the roots and flowers of Delosperma cooperi (Family: Aizoaceae), also known as hard ice-plant by in -vitro protein denaturation method. However, the anti-inflammatory effects of D. cooperi has not been studied. Method: The D. cooperi were extracted by the soxhlation method by using the hydroethanolic solution (60; 40) ratio. Then the extract was evaporated to dryness in order to yield dried crude extract of D. cooperi. The preliminary studies of phytochemicals were done for the confirmation of the presence of active constituents for the effective pharmacological activity. The anti-inflammatory activity was analyzed by using chicken’s egg albumin denaturation method (in-vitro). The hydroethanolic extract was found to have a high ability to inhibit protein denaturation that was evaluated by using a UV spectrophotometer. Result: The extracts of D. cooperi exhibited concentration-dependent protein (Albumin) denaturation inhibition. The effect of the test sample was found to be good when compared...
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Posted by admin on Oct 31, 2020 in |
Starch is a natural polymer and is a group of polysaccharides composed of glucopyranose units joined together by glycosidic linkages. Starch is an important polysaccharide extensively used in many industries like food, cosmetics, paper, textile, pharmaceutical, etc. It is found to be present in appreciable quantity in stem, roots, leaves, seeds, fruits, and tubers. Hence this study was conducted to isolate and characterize starch from the tuber of Antigonon leptopus species. In this work, starch from Antigonon leptopus tubers was extracted, and % starch yield was calculated as well as evaluated for its macroscopic characters, Preliminary phytochemical screening of aqueous extract for the presence of carbohydrate, tannins, saponins, and flavonoids. The result showed that there was a sufficient amount of starch yield. The compound microscope showed the presence of round and oval-shaped small and large starch particles, single as well as in groups. The diamond and prism-shaped calcium oxalate crystals were also seen. Thus, starch of tuber Antigonon leptopus species shows good properties and could serve as alternatives for...
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