REPURPOSING AND PHYTOCHEMICAL INVESTIGATION OF SALACIA OBLONGA ROOT EXTRACT RESPONSIBLE ANTICANCER ACTIVITY AGAINST BREAST CANCER CELL LINE (MCF-7)

Salacia oblonga wall, a native shrub, also known as Saptrangi and Ponkoranti, belongs to the family Celastraceae, is distributed across the world. A large number of chemical constituents such as salacinol, kotalanol, neokotalanol, neosalacinol, and mangiferin are isolated from S. oblonga, which show various pharmacological activities. Salacia oblonga wall is being used in several herbal preparations for treating diabetes and obesity. It possesses anti-inflammatory, antihyperlipidemic, antiperoxidative, antimicrobial, antimutagenic, nephroprotective, and antimutagenic activities. Salacia oblanga has a long history of use as a treatment for diabetes in Ayurveda, traditional Indian medicine. Mugs made from Salacia wood are used by people with diabetes to drink water. In addition to treating diabetes, Salacia is used for treating gonorrhea, asthma, itchiness, joint pain (rheumatism), obesity, thirst, and menstrual problems. Salacia oblonga, an inhabitant of tropical regions, has been used in traditional Indian medicinal systems. Phytochemicals were extracted in methanol from the plant and analyzed for various anticancer activity. This research focuses on extraction, phytochemical investigation of Salacia, and the potential of Salacia oblonga wall in breast cancer by using in-vitro anti-cancer testing on breast cancer cell line (MCF-7).