Posted by admin on Feb 29, 2024 in |
Fast dissolving or mouth disintegrating tablets are oral delivery systems intended for a rapid breakdown of the dosage form in the mouth or oral cavity, in contrast to other conventional dose forms. Labetalol, an alpha-1-adrenergic antagonist of the third generation, has vasodilatory and antihypertensive properties. It is used to treat hypertension and angina. Using novel co-processed super disintegrants and physical combinations combining croscarmellose and crospovidone in 1:1, 1:2, 1:3, 2:1, and 3:1 ratios, this study attempts to produce and evaluate labetalol fast dissolving tablets. The direct compression method was used to make the tablets. The tablets work instantly since they dissolve quickly when used orally. Like liquid dosage forms, orally disintegrating tablets are easier to take and offer greater convenience. Important excipients called disintegrants are added to solid dosage forms in order to break or disintegrate tablets in aqueous media. The disintegrants enhance the formulation’s surface area, or tablet’s surface area, and counteract the cohesive forces that hold the particles...
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Posted by admin on Feb 29, 2024 in |
Objectives: Silymarin is an anti-inflammatory agent that is used in the treatment of a variety of inflammatory disorders. The aim of the present study was to prepare and evaluate novel polymeric nanoparticles containing Silymarin. Materials and Methods: A 32 full factorial design was used to study the effect of Eudragit EPO and Pluronic F-68 on the characterization of nanoparticle suspensions. The polymeric nanoparticles were prepared by Nano precipitation technique. The prepared nanoparticles was evaluated by percentage yield, drug polymer compatibility using Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetric (DSC) analysis, drug content, entrapment efficiency, zeta potential, particle size, scanning electron microscopy, X-ray diffraction, in-vitro drug release studies, kinetic modelling, stability studies, and in-vivo animal studies. Results: The DSC study revealed that the drug was involved in complexation with nanoparticles. The average particle size of Silymarin nanoparticles was in the range of 114.4 nm to 136.7 nm. The zeta potential values were attained to ensure good stability of nanosuspensions. In-vitro release of the drug from nanoparticles follows the...
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Posted by admin on Jan 31, 2024 in |
Medicine presently used to deal with cough are the various maximum notably used over the counter drug treatments in the international, in spite of a recent evaluation suggesting that there is a bit evidence to comparable drug treatments produce any significant efficiency. Syrup is commonly useful and famous dosage form which is used for the remedy of cough and bloodless. We organized the herbal cough syrup by means of including Jaggery base and decoction of natural capsules together with Pudina, Tulsi, Cinnamon, Jaggery and other natural excipients. The natural cough syrup is formulated by using decoction method. Including the decoction of natural capsules with base of Jaggery is beneficial to the formulation for thick and preserves the system. That turned into beneficial to increase the shelf lifestyles of components of natural syrup. The brought Jaggery sweetener also can help to growth the palatability of some natural drugs. The ultimately increase the herbal cough syrup with the bottom of Jaggery. The purpose of this examine is to develop a herbal...
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Posted by admin on Jan 31, 2024 in |
Objective: Major Depressive Disorder (MDD) is a psychological disease with a growing global burden. Oxidative stress has been shown to be a causative mechanism of MDD. This research aimed to evaluate the effect of antioxidant-rich fruits (mango, carrots and watermelon) on oxidative stress markers in rats treated with Dexamethasone to induce depression. Method: Thirty (30) rats were grouped into 5: Group 1 (positive control), Group 2 (treated with 2.6 mg/kg body weight Dexamethasone only), Group 3 (treated with 2.6 mg/kg b.w. Dexamethasone and 10.53ml/kg b.w. of watermelon juice), Group 4 (treated with 2.6 mg/kg body weight Dexamethasone, and 10.53ml/kg b.w. of carrot and mango juice) and Group 5 (treated with Gingko Biloba). The lipid profile and C-reactive protein (CRP) were determined using blood samples. Brain homogenate was used to determine oxidative stress parameters SOD, GPx, GSH, MDA, and serotonin levels. Results: Results of the research showed a significant increase in HDL and a significant decrease in LDL, TAG and MDA levels in Group 4. A significant increase was observed...
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Posted by admin on Dec 31, 2023 in |
Clinical studies have demonstrated the benefits of herbs and herbal oil for hair growth. The primary issues linked to hair loss include dandruff, hair fading, and hair falling out, which are issues that both men and women find quite concerning. There are some synthetic medications for hair loss which exhibit serious adverse effects in addition to not providing an effective cure. The primary goal of this work is to create a herbal hair oil formulation that can address hair loss and other hair-related issues. Herbs like Murraya koenigii, Lawsonia inermis, Azadirachta indica, Vitex negundo, Phyllanthus emblica, Centella asiatica, Hibiscus rosa sinensis cederwood oil and Rosmerry oil were selected for the formulations of hair fall control herbal hair...
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