DEVELOPMENT AND ASSESSMENT OF LABETALOL RAPID DISSOLVING TABLETS
AbstractFast dissolving or mouth disintegrating tablets are oral delivery systems intended for a rapid breakdown of the dosage form in the mouth or oral cavity, in contrast to other conventional dose forms. Labetalol, an alpha-1-adrenergic antagonist of the third generation, has vasodilatory and antihypertensive properties. It is used to treat hypertension and angina. Using novel co-processed super disintegrants and physical combinations combining croscarmellose and crospovidone in 1:1, 1:2, 1:3, 2:1, and 3:1 ratios, this study attempts to produce and evaluate labetalol fast dissolving tablets. The direct compression method was used to make the tablets. The tablets work instantly since they dissolve quickly when used orally. Like liquid dosage forms, orally disintegrating tablets are easier to take and offer greater convenience. Important excipients called disintegrants are added to solid dosage forms in order to break or disintegrate tablets in aqueous media. The disintegrants enhance the formulation’s surface area, or tablet’s surface area, and counteract the cohesive forces that hold the particles together.
Article Information
6
100-106
671 KB
415
English
IJP
Pushpendra *, Tulsi Bisht and Ankit Goel
Kunti Naman Institute of Pharma Technology & Science, Roorkee, Haridwar, Uttarakhand, India.
pusp92744@gmail.com
22 February 2024
12 March 2024
27 March 2024
10.13040/IJPSR.0975-8232.IJP.11(3).100-06
31 March 2024
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