TOXICOLOGICAL STUDY OF THE METHANOL LEAF EXTRACT OF BAPHIA PUBESCENS HOOK, F. FAMILY LEGUMINOSAE
AbstractSince time immemorial, natural products have been the backbone of traditional system of healing throughout the globe and have also been an integral part of history and culture. Hence Baphia pubescence has been used ethnomedicinally to treat various diseases. The leaf or leaf juice is applied against parasitic skin diseases. A leaf infusion is drunk to cure enteritis and other gastrointestinal problems. The leaves and bark are considered haemostatic and anti-inflammatory and are used for healing sores and wounds. The leaves infusion is used to treat malarial infections as well as other microbial infections. As a result, it is pertinent to study the toxicity of the plant. The toxicological study both acute and chronic were evaluated according to standard methods. Acute andChronic toxicity studies of B. pubescens indicated that the plant is relatively safe at the therapeutic dose. The toxicity of the plant was shown to be dose dependent. The kidney and liver enzymes increased with increasing doses whereas the histopathological damage after long administration on these organs was mild.
Article Information
4
200-209
1914 KB
111
English
IJP
Anowi Chinedu Fredrick *, Ezea Charity Chinasa and C. C. A. Azikiwe
Department of Pharmacognosy and Traditional Medicine, Nnamdi Azikiwe University Awka, Nigeria.
cf.anowi@unizik.edu.ng
10 May 2024
26 May 2024
29 May 2024
10.13040/IJPSR.0975-8232.IJP.11(5).200-09
31 May 2024