STUDY OF ANTI-DIABETIC ACTION OF NYMPHAEA NOUCHALI FLOWER EXTRACT IN ALLOXAN-INDUCED DIABETES IN RATS
AbstractThe present work focused on preparing ethanolic extract of Nymphae nouchali flower and evaluating its anti-diabetic potential in rats. The extraction of flowers was carried out using ethanol and the extraction yield was found to be 18.6% w/w. The result of the total phenolic content of the extract examined using Folin-Ciocalteu method revealed total phenolic content of ethanolic extract of Nymphae nouchali was 41.26 ± 2.13 GAE mg/g. The antidiabetic action of the extract was evaluated in terms of the effect of extract on body weight and serum glucose level. It was found that alloxan administration reduced the body weight of animals significantly in comparison with the normal control animals. The results also revealed that the serum glucose levels were highly elevated by the administration of alloxan in all the groups by day 7. In the treatment groups III to V, the glucose levels dropped in comparison to group II and by day 21, the levels reached almost the level of control group in group III and V. This indicates that the extract exhibits significant glucose lowering potential.
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