Posted by admin on Jul 31, 2026 in |
Type 2 Diabetes Mellitus (T2DM) is characterized by insulin resistance and impaired glucose metabolism. With the rising interest in plant-based interventions, Sterculia foetida seeds have attracted attention for their potential antidiabetic properties. This study aimed to evaluate the effects of Sterculia foetida seed extract on insulin resistance in a rat model of T2DM. Male Wistar rats were divided into normal, diabetic control, and treatment groups. T2DM was induced using a combination of high-fat diet and low-dose streptozotocin (STZ). After confirmation of diabetes, rats in the treatment group received Sterculia foetida seed extract orally for a specified duration. Fasting blood glucose, serum insulin levels, and insulin resistance (assessed by HOMA-IR) were measured. Additional biochemical parameters and histopathological examination of pancreatic tissues were conducted. Treatment with Sterculia foetida significantly reduced fasting blood glucose and HOMA-IR values compared to the diabetic control group. Serum insulin levels improved, indicating enhanced insulin sensitivity. Histological analysis supported these findings, showing improved islet morphology in treated rats. Sterculia foetida seed extract demonstrated promising effects in reducing...
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Posted by admin on Jul 31, 2026 in |
Tectona grandis and Annona squamosa are two medicinal plants of Lamiaceae and Annonaceae families respectively. Both of them are traditionally used to treat various diseases. As cancer is a life-threatening disease and cervical cancer is one of the most dangerous types of cancer, currently researchers’ goal is to investigate natural sources of anticancer agents. The objective of the present research is to investigate the preliminary phytochemicals and qualitative anticancer activity of the ethanolic leaves extracts of these two plants. Standard methods of phytochemical scrrening were employed to identify the secondary metabolites including carbohydrates, glycosides, saponins, steroids, flavonoids, tannins, phenols, coumarins, resins, and alkaloids. Besides, qualitative anticancer activity on HeLa cell line was investigated for these two plants from Centre for Advanced Research in Science (CARS), Dhaka, Bangladesh, using their standard procedure. Preliminary phytochemical analysis revealed the presence of steroids, tannin and alkaloids in the ethanolic extract of leaves of Tectona grandis and it is revealed that carbohydrates, glycosides, steroids, tannins, alkaloids, flavonoids, phenolic compounds, and coumarins were present in...
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Posted by admin on Jul 31, 2026 in |
The present study was designed to develop, optimise, and comprehensively evaluate a polyherbal antimicrobial gel made up from Azadirachta indica, Curcuma longa, Curcuma longa, Aloe vera, and Centella asiatica. Dry powder extracts were subjected to preliminary phytochemical screening, quantitative estimation of total phenolic content (TPC) and total flavonoid content (TFC), and validated HPTL.C In vitro antimicrobial activity of individual and combined extracts was evaluated by disc diffusion, broth microdilution minimum inhibitory concentration (MIC) determination, and checkerboard synergy assay (Fractional Inhibitory Concentration Index, FICI). Three polyherbal gel formulations (F1, F2, F3) were prepared using Carbopol 940 at 0.5%, 1.0%, and 1.5% w/w respectively. Physicochemical evaluation, in vitro antimicrobial activity by agar well diffusion, in vitro drug release, accelerated stability studies, and primary skin irritation by Draize patch test were performed. All five plant extracts demonstrated broad-spectrum antimicrobial activity. Formulation F2 (Carbopol 940, 1.0% w/w) was identified as optimal: pH 6.1 ± 0.1, viscosity 6,180 ± 204 cP, spreadability 8.2 ± 0.4 g.cm/s, and drug content within 95–105% for all markers....
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Posted by admin on Jul 31, 2026 in |
Background/Objective: Inflammation is a protective response of the body against harmful stimuli such as pathogens, tissue injury and irritants however, chronic inflammation is associated with ailments including Arthritis, Cardiovascular disorders and autoimmune conditions. Methods: Dried leaves of both the species were extracted by maceration using 70% ethanol and concentrated by rotary evaporator. The present study aimed to evaluate the phytochemicals and anti-inflammatory activity of two Amaranthus species- Amaranthus dubius and Amaranthus cruentus through the inhibition of protein denaturation using the Egg Albumin assay. Results: The extract of both species of Amaranthus exhibited the presence of bioactive phytochemicals such as Carbohydrates, Proteins, Flavonoids, Alkaloids, Tannins, Glycosides, etc. confirmed by phytochemical analysis. The extract demonstrated significant anti-inflammatory potential showing a concentration dependent increase in inhibition, which indicates effective protection of proteins from structural damage associated with inflammatory conditions. Furthermore, the formulated Amaranthus based ointment exhibited physicochemical characteristics suggesting its suitability for topical application, although further stability and antimicrobial studies are required in this context to validate the same. Conclusion: The significant...
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Posted by admin on Jun 30, 2026 in |
Exposure to ultraviolet (UV) radiation from sunlight is a major cause of skin damage, premature aging, and skin cancer. Sunscreen creams are widely used to protect the skin from harmful UV rays; however, the long-term use of synthetic sunscreens may cause skin irritation and other adverse effects. Therefore, there is growing interest in the development of herbal sunscreen formulations using natural ingredients. The present study focuses on the formulation, characterization, and evaluation of a herbal sunscreen cream using sesame oil as the main active ingredient. Sesame oil is rich in natural antioxidants such as sesamol and sesamin, which exhibit UV-absorbing and free-radical scavenging properties. In this study, an oil-in-water type herbal sunscreen cream was formulated using sesame oil along with suitable excipients such as emulsifiers, preservatives, and stabilizers. The prepared formulation was subjected to characterization tests including physical appearance, pH, viscosity, spreadability, homogeneity, and type of emulsion to ensure formulation quality and stability. The evaluation of the herbal sunscreen cream was carried out to assess its sun-protective and safety...
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