Posted by admin on Feb 28, 2026 in |
The present study evaluates the antidiabetic potential of hydroalcoholic extracts derived from the fruit and peel of Ananas comosus (pineapple). Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia resulting from impaired insulin secretion or action. Natural plant-based remedies have gained attention for their efficacy and minimal side effects. The hydroalcoholic extracts were prepared using standardized extraction methods and subjected to phytochemical screening to identify bioactive constituents. The antidiabetic activity was assessed using in-vivo models of diabetes induced in experimental animals. Blood glucose levels and body weight were monitored throughout the treatment period. Results demonstrated a significant reduction in fasting blood glucose levels and improvement in lipid profile in animals treated with both fruit and peel extracts, with peel extract exhibiting comparatively higher efficacy. The findings suggest that Ananas comosus hydroalcoholic extracts possess promising antidiabetic properties, potentially attributable to their rich phytochemical content, including flavonoids, phenolics, and enzymes. These results warrant further studies to isolate specific active compounds and elucidate underlying mechanisms for clinical application in diabetes...
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Posted by admin on Feb 28, 2026 in |
Background and Aim: Phenanthrene is an aromatic compound with three benzene rings forming the main structure. It represents the majority of polycyclic aromatic hydrocarbons found in the environment and is found in a variety of areas including, burnt smoky coal particles soil and sediment, diesel emissions, tobacco and food smoke. The aim of the study was to determine the effect of phenanthrene on oxidative stress markers in male Wistar rats. Methodology: Fifty healthy rats weighing between 100 and 180g were used for this study. The animals were randomly assigned into five groups of ten rats per group. Group A served as control and the animals were administered with 1ml of DMSO oil only orally for three weeks. Groups B animals were administered orally with 5mg/kg of phenanthrene dissolved in 9ml of DMSO oil and Group C animals were administered orally with 10mg/kg of phenanthrene dissolved in 13ml of DMSO oil for three weeks. Group D animals, had 180mg/kg of phenanthrene dissolved in 1ml of DMSO oil orally, once, while...
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Posted by admin on Feb 28, 2026 in |
This study investigated four medicinal plants Moringa oleifera leaves, Hippophae rhamnoides (Sea buckthorn) berries, Syzygium cumini seeds, and Psidium guajava leaves for their suitability in developing a polyherbal antidiabetic syrup. Hydroalcoholic extracts were prepared through maceration and yielded diverse phytochemical constituents, including flavonoids, alkaloids, saponins, glycosides, tannins, and phenols. Among the plants, Syzygium cumini exhibited the richest phytochemical profile, while Sea buckthorn uniquely contained terpenoids and steroids. Three syrup formulations were evaluated and found to possess acceptable physicochemical properties, with Formulation 2 demonstrating optimal viscosity, pH, and palatability. In-vitro antidiabetic analysis showed that all extracts inhibited α-amylase, while Syzygium cumini and Moringa oleifera demonstrated dual inhibition of α-amylase and α-glucosidase, though with higher IC₅₀ values than Acarbose. Overall, the results support the potential of these plants particularly Syzygium cumini for use in a synergistic polyherbal syrup aimed at managing diabetes through digestive enzyme inhibition. Further in-vivo and clinical investigations are recommended to confirm efficacy and...
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Posted by admin on Jan 30, 2026 in |
The aqueous leaf extract of Corchorus olitorius Linn. (Family, Tiliaceae) and Carica papaya Linn. (Family, Caricaceae) was screened for in-vitro anthelmintic activity against earthworms (Pheretima posthuma) by brine shrimp lethality bioassay. The extract showed anthelmintic activity at all the concentrations of 100mg/ml, 50mg/ml and 25mg/ml. However, at a dosage of 100 mg/ml, strong anthelmintic action was identified. The time needed for earthworms to become paralyzed and death at this concentration was Corchorus olitorius Linn. about 80 and 120 minutes (conc. 100mg/ml) and Carica papaya Linn. about 74 and 90 minutes(Conc. 100mg/ml) whereas time taken for paralysis and death by the standard drug Albendazole at 50mg/ml was about 180 and 203 minutes respectively. The experimental results suggest that Corchorus olitorius Linn. and Carica papaya Linn. has in-vitro anthelmintic...
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Posted by admin on Jan 30, 2026 in |
The rising demand for natural and skin-friendly personal care products has prompted the exploration of plant-based formulations. This study focuses on the development and evaluation of an organic herbal cleanser incorporating Spinacia oleracea (spinach) and Murraya koenigii (curry leaf) extracts, known for their antioxidant, anti-inflammatory, and antimicrobial properties. Two gel-based formulations were prepared using Carbopol 934 as a gelling agent, glycerine as a humectant, and sodium lauryl sulfate as a foaming agent. Formulations were evaluated for physical characteristics, pH, spread ability, washability, and foamability. Both formulations exhibited pale green color, smooth consistency, pleasant herbaceous aroma, and easy washability. Among the two, formulation F2 demonstrated superior gel formation, optimal pH (5.2), excellent spreadability, and stable foam. Preliminary phytochemical analysis confirmed the presence of flavonoids, alkaloids, tannins, steroids, and glycosides in the extracts, supporting their bioactive potential. The results suggest that the developed herbal cleanser is safe, effective, and cosmetically acceptable for routine facial care. This eco-friendly, plant-powered formulation offers a promising alternative to synthetic cleansers, aligning with the growing trend...
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