Posted by admin on Jun 30, 2026 in |
The evolution of helminthes drug resistance and the increased expense of traditional medications have spurred investigation into medicinal plants as potential alternatives to anthelmintics. Utilizing P. posthuma, the present study focuses on the anthelmintic activity of three traditionally used plants in Bangladesh. Mimosa pudica (family: fabaceae), Terminalia bellirica (family: Combretaceae), Calotropis gigantea (family: Apocynaceae). At all tested concentrations (25, 50 and 100 mg/ml), of the plant extract showed a significant anthelmintic effect. The highest activity or effectiveness was observed at 100 mg/ml. At these maximum concentrations, Calotropis gigantea showed the most potent anthelmintic effect among the plants, achieving paralysis in 19 ±5 minutes and death time in 86 ± minutes. This was succeeded by Terminalia bellirica (paralysis at 43 ±5min and death at 185±5 minutes) and Mimosa pudica (paralysis at 58 ± 5 minutes and death at 229 ±5 minutes). This result supports the traditional use of these plant-based anthelmintic...
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Posted by admin on Jun 30, 2026 in |
In pursuit of anticancer metabolites from natural sources, we examined organic extracts of Solanum incanum berries collected in Oman. The ethyl acetate fraction demonstrated significant inhibition of Carbonic Anhydrase (CA) activity, with an IC₅₀ value of 20.20 ± 1.2 µg/ml. From this fraction, a β-sitosterol derivative was isolated and shown to suppress the proliferation of MCF-7 breast cancer cells by 71.5% in the MTT assay. These findings suggest that S. incanum represents a promising source of potential anticancer...
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Posted by admin on May 31, 2026 in |
The present study focuses on the formulation and evaluation of a herbal hair mask using natural ingredients as a safer alternative to synthetic hair care products. The formulation incorporates plant-based components such as flaxseed, fenugreek, aloe vera, and hibiscus, which are known for their nourishing, conditioning, and hair growth–promoting properties. The hair mask was prepared using Carbopol 940 as a gelling agent, glycerin as a humectant, sodium benzoate as a preservative, and triethanolamine for pH adjustment. Two formulations (F1 and F2) were developed and evaluated for various parameters including organoleptic properties, pH, spreadability, stability, and skin irritation. The prepared formulations exhibited a pleasant odor, smooth texture, and appropriate pH suitable for scalp application. Stability studies showed no significant changes in color, odor, texture, or pH under different storage conditions, indicating good stability. The skin irritation test confirmed that the formulation was non-irritant and safe for topical use. Overall, the herbal hair mask demonstrated effective conditioning, moisturizing, and potential anti-dandruff and hair-strengthening properties. The study concludes that the formulated herbal...
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Posted by admin on May 31, 2026 in |
The present study aimed to optimize sodium bicarbonate-based effervescent tablets using natural binders through a systematic Design of Experiments (DoE) approach. A Box–Behnken design was employed to evaluate the influence of sodium alginate, sodium bicarbonate, and microcrystalline cellulose (MCC) on formulation parameters. Seven initial formulations (F1–F7) were prepared using different natural binders including fenugreek mucilage, fenugreek powder, acacia, tragacanth, sodium alginate, and guar gum. Based on pre-compression evaluation, sodium alginate (F6) demonstrated superior flowability and compressibility. Further DoE-based optimization using 17 formulations revealed that sodium bicarbonate concentration significantly reduced effervescence time, while sodium alginate enhanced tablet hardness and MCC improved flow characteristics. The optimized formulation (0.10 g sodium alginate, 0.20 g sodium bicarbonate, 1.75 g MCC) exhibited rapid effervescence (10–25 s), acceptable pH (2.88–3.92), adequate hardness (5.35 kg/cm²), and excellent flow properties (Carr’s index 22.5%). ANOVA confirmed model significance (R² > 0.93), supporting the efficacy of natural binders as eco-friendly, safe alternatives to synthetic excipients in effervescent tablet...
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Posted by admin on May 31, 2026 in |
Background/Objective: Calamus tenuis Roxb. (family Arecaceae) is a climbing palm used in traditional medicine across South and Southeast Asia for treating fever, hemorrhoids, bacterial infections, inflammation, diabetes, and gastric complaints. Despite its ethnomedicinal importance, information on the thrombolytic potential of its leaves remains scarce. This study aimed to investigate the phytochemical composition, antioxidant capacity, and thrombolytic activity of the methanolic extract of C. tenuis leaves. Methods: Dried leaves were subjected to cold maceration in methanol for 15 days, and the crude extract was obtained by rotary evaporation. Qualitative phytochemical screening was performed using standard colorimetric tests. Antioxidant activity was assessed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay using a natural logarithmic regression curve fit, and thrombolytic activity was evaluated by an ex-vivo clot lysis assay using streptokinase as the standard and distilled water as a negativecontrol. Results: Phytochemical screening confirmed the presence of alkaloids, carbohydrates, saponins, flavonoids, steroids, glycosides, and tannins. Natural logarithmic regression analysis optimized the evaluation of antioxidant capabilities, generating a precise fit line (y =...
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