Posted by admin on Nov 1, 2014 in |
Garlic is one of the earliest well known medicinal plants, which used to cure different disease in a human being. It used to fight infections, prevent cancer, antidiabetic, hepatoprotective, anthelmintic, anti- antioxidant, and wound healing. Based on the above important of garlic, this study was conducted to investigate the antibacterial activity of garlic extracts (ethanol, acetone and aqueous extracts) against bacterial strains. The antibacterial activity of garlic was tested against gram-positive Bacillus subtitles and gram-negative E. coli bacterial strains by using agar well diffusion method. The results reveal that garlic extract shows inhibitory activity against gram-positive bacteria Bacillus subtilis and gram-negative E. coli bacterial strains. The maximum zone of inhibitions observed against Bacillus subtilis with the combination (32 mm), aqueous (30 mm), ethanol (26 mm), and acetone (22 mm) extracts, respectively. Minimum inhibition zone was observed in all extracts against Gram-negative Bacteria (E. coli), i.e. combination (21 mm), aqueous (16 mm), ethanol (14 mm), and acetone (12 mm). The results showed that B. subtilus is more susceptible to garlic...
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Posted by admin on Nov 1, 2014 in |
Infertility is one of the most extremely tragic all over the world. Despite recent advances in the treatment of male infertility, the problem has not been satisfactorily tackled. The male infertility is mainly due to an inadequate number of spermatozoa in the semen, the failure of the spermatozoa to move with sufficient vigor towards their goal. Herbal medicines have been broadly used in developed countries hence they are natural and comparatively safe. They contain plant materials as their pharmacologically active components. The aim of the study is to evaluate the acute and sub-acute toxicity of the spermatogenic Siddha drug Magizhampattai Chooranam (MPC). For acute studies, different doses of MPC were administered orally to rats once daily for one week. For sub-acute studies, different doses of IC were administered orally to rats once daily for 28 days in various doses at 250, 500, 1000 mg/kg of body weight. Detailed hematological, biochemical, necropsy and Histopathological evaluation of organs were performed for all animals. Histopathological analysis revealed that Spleen, Testes, Pancreas, Lung,...
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Posted by admin on Nov 1, 2014 in |
Desmostachya bipinnata (L.) Stapf [Gramineae (Poaceae)] is used in Indian traditional medicines system for treatment of various diseases such as asthma, kidney stone, diarrhea, wound healing, etc. These traditional claims require authentication by performing animal testing. This study aims to confirm the antidiarrheal activity of D. bipinnata in Wistar rats. Underground parts of D. bipinnata was extracted in alcohol, water, a hydroalcoholic solution, chloroform, and ethyl acetate. Acute toxicity test was performed in albino mice and antidiarrheal activity was estimated in Wistar rats. Castor oil and magnesium sulfate-induced diarrhea in Wistar rats were treated with single oral administration of prepared D. bipinnata extracts (500 mg/kg) and antidiarrheal drug loperamide (3 mg/kg). Diarrhoeal droppings were observed for 6 h in all treated animals. One way ANOVA followed by Dunnet’s ‘t’ test was used to identify significant differences among obtained results. Extracts of D. bipinnata showed neither mortality nor any toxic effect in albino mice up to the dose of 5 g/kg in 48 h to 14 days. The alcohol extract of...
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Posted by admin on Nov 1, 2014 in |
The inhibitory effects of ethyl acetate, aqueous and ethanolic extracts of Talinum triangulare were well observed in the brain homogenate of Swiss albino rats against sodium nitroprusside induced-peroxidation by thiobarbituric acid reactive species (TBARS) in-vitro. All the extracts showed significant inhibitory abilities against sodium-nitroprusside (SNP) induced lipid peroxidation in the brain homogenate when incubated with 60mM sodium nitroprusside. In the current work, aqueous extract of Talinum triangulare seems to possess higher antioxidant contents with the fact that it shows the highest inhibition potential against SNP-induced peroxidation in the brain tissue homogenate from the results, thereby characterize the ability to protect the brain cell and as well able to prevent nitrosative stress induction at considerable measure in the...
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Posted by admin on Nov 1, 2014 in |
In folk medicine, Aloe camperi, Aloe percrassa (Aloeceae), and Senna singueana L. (Fabaceae) are used in the management of infectious and inflammation-related disorders. The objective of this work was to evaluate the in-vitro hyaluronidase inhibition activities of extracts from these three medicinal plants. Various concentrations (10, 50, and 100 µg/ml) of leaf latex from the two Aloe sp and hydro alcoholic extract of S. singueana leaves were screened using hyaluronidase inhibition assay. The results showed that all the three extracts displayed concentration-dependent inhibitory activities with IC50 values of 771.78, 664.47 and 630.83 μg/ml for A. camperi, A. Percrassa and S. singueana, respectively. Indomethacin, used as a standard drug in this study, showed IC50 value of 27.95μg/ml. Hyaluronidase hydrolyzes hyaluronic acid in the extracellular matrix during tissue remodeling. Since, oligomers from hyaluronic acid degradation are associated with induction of inflammation and hyaluronidase activity up-regulation occurs in chronic inflammatory conditions, hyaluronidase inhibitors are suggested to have a beneficial role in prevention and treatment of inflammation-related disorders. Thus, the hyaluronidase enzyme inhibition...
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