Posted by admin on May 31, 2022 in |
Using the plant as a source of medicine is one of the major campaigns in the field of alternative therapy. This study was conducted to investigate the antimicrobial activity of Leptadenia hastate root. The root of this plant was collected, dried, and ground. The powder was subjected to extraction by cold maceration using water and methanol. The in-vitro antimicrobial activity of the extract was tested against four strains of bacteria: Staphylococcus aureus, Pseudomonas aeruginosa, E. coli, Bacillus cereus and one fungus Candida albicans using the agar diffusion method. DMSO was used as a negative control; Ciprofloxacin was used as a positive control for bacteria and fluconazole as a positive control for fungi. The agar dilution method determined the minimum inhibitory concentration (MIC) of crude extract. The phytochemical analysis was conducted to determine the secondary metabolites. The antimicrobial activities show that methanol extract of Leptadenia hastate was only sensitive against Bacillus cereus and Candida albicans out of five organisms tested, while aqueous extract does not show activity against any organism...
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Posted by admin on Apr 30, 2022 in |
Inflammation is initiated as a healing process by the tissue in response to an injury by pathogens, irritants or cell damage. Piper attenuatum B. Ham is a rare piper species found in the tropical, sub-tropical region and mainly found in the southern part of India. A plant has constituents like alkaloids, amides, glycosides, tannins etc., which are responsible for its therapeutic efficacy. This research focuses on the use of leaves of Piper attenuatum B. Ham as anti-inflammatory agents. The phytochemical and analytical evaluation was done for ethanolic leaf extract. Various part of the plant is used for treating fever, malaria, diuretic, and cancer. Piperine is a major alkaloid found in almost all piper species & responsible for anti-inflammatory activity. In the present study, ethanolic leaf extract of Piper attenuatum B. Ham at doses 200mg/kg and 400mg/kg showed significant in-vivo anti-inflammatory activity in carrageenan-induced paw edema in rats and in-vitro anti-inflammatory activity by protein denaturation method for dose 500, 400, 300, 200 & 100...
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Posted by admin on Mar 31, 2022 in |
Essential oils are largely employed for their therapeutic properties, and marketed extensively in the pharmaceutical and cosmetic industry. Geranium oil is a floral substitute for rose essential oil with its pungent rose-like odor and is one of the most valuable essential oils. Favorable quality properties make the geranium essential oil exigible for food industry applications. Our study aimed to assess the purity and quality of geranium oil available from various commercial producers. The gas chromatography-mass spectrometry (GC-MS) technique was used to detect and quantify the volatile constituents of geranium essential oil. 40 (fourty) volatile compounds were determined by the GC-MS method. The most abundant compounds were determined as geraniol (27.98%), citronellol (20.71%), isomenthone (6.57%), geranyl formate (6.52%) and linalool...
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Posted by admin on Mar 31, 2022 in |
Medicinal plants have been estimated as the richest holdings of traditional medicines and from these plants, many types of modern medicines were developed. Coscinium fenestratum (Gaertn.) Colebr. belongs to the family Menispermaceae and is considered a critically endangered medicinal plant. Traditionally it is used for antimicrobial agents, diabetes mellitus, cancer, and arthritis. In this study in-vitro pharmacological activities of leaf and stem extracts of C. fenestratum were evaluated. The solvent extracts were screened for antimicrobial activity against some clinically isolated bacterial and fungal cultures using the disc diffusion method. The antioxidant activity of extracts were tested by 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The acetone extract of stem showed potential antimicrobial activity than other extracts. All the pathogens were inhibited at very low concentration, very specific Klepsiella pneumoniae was inhibited at 0.156mg/mL and Phialophora verrucosa was inhibited at 0.078mg/mL of the stem extract. The methanol extracts of stem showed the highest antioxidant activity of 99.59%. followed by stem extracts of ethyl acetate (99.02%), acetone (98.79%), and petroleum ether(90.55%) were showed. Hence, the...
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Posted by admin on Feb 28, 2022 in |
Traditional knowledge and ethnobotanical use of plants have been widely acknowledged worldwide. The cicatrizing properties of extracts obtained from this plant have been scientifically studied, attributing the main biological activity to its tannin and flavonoid content. The recent commercialization of the plant drug Gynura nepalensis. requires Pharma-cognostical and Pharmacological information to develop quality-control methods for raw materials and extracts produced with the plant drug. Macro and micro morphological parameters were established to authenticate the genuine drug that allowed detection of adulterants usually found in commercial samples of this plant material. All the parameters were studied according to WHO guidelines and Indian Pharmacopoeia. These morphological characteristics can be used for rapid identification of the drug and are particularly useful in the case of powdered materials and physicochemical parameters. TLC profiling of plant extracts gives an idea about the presence of various phytochemicals. Pharmacological activity of Gynura nepalensis ethanolic leaf extracts were analyzed for total phenolic and flavonoid contents along with the antioxidant, antimicrobial and anti-inflammatory activity. The result of the...
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