ADVANCED ANALYTICAL APPROACH FOR THE QUANTIFICATION OF POTASSIUM IODIDE IN HERBAL FORMULATIONS AND PHARMACEUTICAL SAMPLES BY USING INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY (ICP-MS)
AbstractThis research demonstrates the use of inductively coupled plasma-mass spectrometry (ICP-MS) following microwave digestion in the estimation of the quantity of iodine in pharmaceutical samples and herbal formulations. The samples were dissolved in 4 mL of a 2% Tetra-methyl-ammonium-hydroxide solution, and iodine was used as a reference standard. Collectively, the findings show that the method was linear with calibration curves ranging from 1 ppb to 100 ppb. The recoveries of the examined samples fell between 98 and 115%. The precision of repeatability for iodine concentration ranged from 2.11% to 2.85% for intermediate precision. The present method is robust according to the percentage of RSD of robustness test under various modified conditions. For herbal formulations and pharmaceutical samples, validated methods were proved to be applicable, sensitive, accurate, and reliable.
Article Information
11
234-239
565 KB
92
English
IJP
Krishnaji Kulkarni *, Rajendra Bojanala and N. S. Prakash
Analytical Development, R&D Himalaya Wellness Company, Makali, Tumkur Road, Bengaluru, Karnataka, India.
Krishna.kulkarni@himalayawellness.com
11 March 2025
24 March 2025
26 March 2025
10.13040/IJPSR.0975-8232.IJP.12(3).234-39
31 March 2025
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