ANALGESIC AND CNS DEPRESSANT ACTIVITIES OF THE METHANOLIC EXTRACT OF HEMIGRAPHIS HIRTA
AbstractHemigraphis hirta, a member of the Acanthaceae family, is locally known as buripana and borati gas and widely considered a medicinal plant in its native Bangladesh. It has been utilized for treating abdominal pain, glossitis, stomatitis, acute wounds, and helmintic infections. Analgesic activity was studied in rats using acetic acid induced writhing method. Diclofenac sodium25 mg/kg and vehicle served as standard and control respectively. Two doses 200 mg/kg and 400 mg/kg of plant extract exhibited significant (P<0.05) analgesic activity in acetic acid induced writhing method in comparison to control.CNS depressant activity was studied in mice by open field and hole cross methods respectively. In both models, the standard drug used was Dizepam2 mg/kg. The two doses of plant extract exhibited significant CNS depressant activity in open field (P<0.05) and hole cross tests in comparison to control. In conclusion H. hirta possesses analgesic and CNS depressant activities.
Article Information
10
228-233
505 KB
99
English
IJP
Taslima Begum, Mahmuda Nasrin, Monira Ahsan and Pritesh Ranjan Dash *
Department of Pharmacy, Primeasia University, Banani, Dhaka, Bangladesh.
pritesh@primeasia.edu.bd
05 March 2025
18 March 2025
26 March 2025
10.13040/IJPSR.0975-8232.IJP.12(3).228-33
31 March 2025
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