Posted by admin on Apr 29, 2015 in |
The present study was to investigate the antioxidant activity of aqueous bark extract of Spondias pinnata (Linn. f.) Kurz (Family: Anacardiaceae) in streptozotocin-induced diabetic rats. The antioxidant activity was evaluated by the activities of liver enzymes, antioxidant enzymes, and the extent of lipid peroxidation (LPO) in the liver of streptozotocin (STZ) ‑diabetic rats. S. pinnata extract decreased the LPO by 17%, activities of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase decreased by 20%, 17% and 36% respectively (P<0.05). The liver reduced glutathione, activities of glutathione reductase, glutathione peroxidase, and glutathione S-transferase of plant extract treated diabetic rats were increased by 43%, 44%, 69% and 52% respectively (P<0.05). The light microscopic appearance of the liver tissue in S. pinnata treated rats has corroborated the biochemical results. The present investigation revealed that the bark extract of S. pinnata exerts significant in-vivo antioxidant activities in diabetic...
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Posted by admin on Apr 6, 2015 in |
In the present study, an indigenous herbal formulation containing the ethanolic extracts of rhizomes of Curcuma longa, fruits of Terminalia chebula, leaves of Azadirachta indica, leaves of Lawsonia inermis and leaves of Achyranthus asperus were prepared and studied for its wound healing activity in an ointment base by using in in-vivo excision wound model in albino wistar rats. The ointment was prepared with extracts in three different concentrations, i.e., 1%, 2% and 3% (w/w) and applied on excision wound twice daily for 16 days. Povidone-iodine was used as reference standard. It was observed that the wound healing contracting ability of the polyherbal extract in ointment base in different concentrations was significantly p<0.01 superior to that of the control (i.e., simple ointment treated group). The epithelialization time in the treated group was found to be less as compared to control. The most effective concentration of the polyherbal extract in ointment base was found to be 3% (w/w) for wound...
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Posted by admin on Apr 6, 2015 in |
In this study, the cream was formulated from the plant extract containing anti-oxidant ingredient Embelin and its quality control evaluation performed along with the antioxidant activity. The alcohol extract of the plant was used. The extract was tested for antioxidant activity by superoxide scavenging activity. Quality evaluation of the product was assessed by using different evaluation methods. The stability study was also performed, and no changes in the physical properties were observed. The formulations showed good spreadability, no evidence of phase separation and good consistency during this study period. The cream was found to be stable during the stability study. From the present study, it was concluded that it is possible to develop creams containing herbal extract having antioxidant...
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Posted by admin on Apr 6, 2015 in |
Many plants used as traditional medicine. Pharmacognostic studies of crude drug play a very important role in the identification of the purity and quality of crude drugs. The present study deals with the pharmacognostic, preliminary phytochemical investigation of Cynodon dactylon Persoon belonging to family Poaceae. In this, pharmacognostic studies are concerned for the determination of physicochemical parameters like ash values, extractive values, and loss on drying fluorescence analysis also the macroscopic and microscopic evaluation carried out. .The leaves were subjected to successive soxhlation using petroleum ether, ethyl acetate, alcohol, and water. The extracts thus obtained were studied for preliminary phytochemical investigation for detection of the presence of various chemical constituents like alkaloids, glycosides, steroids, tannins, saponins, fats and oils, flavonoids,...
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Posted by admin on Apr 6, 2015 in |
A rapid, simple, selective and precise UV-Visible spectrophotometric method has been developed for the determination of Curcumin in bulk and nano-formulation. The spectrophotometric detection was carried out at an absorption maximum of 421 nm using methanol as solvent. The method was validated for various validation parameters. The linearity range was found to be 5-25 μg/ml with a correlation coefficient of 0.9997. The accuracy was found to be within the limit. The LOD and LOQ were found to be 0.4 and 1.21 μg/ml; respectively. The results demonstrated that the method could be conveniently employed for routine quality control analysis of Curcumin in bulk and...
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