POLY HERBAL THERAPY IN OINTMENT BASE FOR WOUND HEALING ACTIVITY IN RATSAbstract
In the present study, an indigenous herbal formulation containing the ethanolic extracts of rhizomes of Curcuma longa, fruits of Terminalia chebula, leaves of Azadirachta indica, leaves of Lawsonia inermis and leaves of Achyranthus asperus were prepared and studied for its wound healing activity in an ointment base by using in in-vivo excision wound model in albino wistar rats. The ointment was prepared with extracts in three different concentrations, i.e., 1%, 2% and 3% (w/w) and applied on excision wound twice daily for 16 days. Povidone-iodine was used as reference standard. It was observed that the wound healing contracting ability of the polyherbal extract in ointment base in different concentrations was significantly p<0.01 superior to that of the control (i.e., simple ointment treated group). The epithelialization time in the treated group was found to be less as compared to control. The most effective concentration of the polyherbal extract in ointment base was found to be 3% (w/w) for wound healing.
N. K. Mishra * and M. Pallavi
Yalamarty Pharmacy College, Yalamarty Nagar, Tarluwada, Visakhapatnum, Andhra Pradesh, India.
27 November 2014
04 February 2015
27 February 2015
01 March 2015