Posted by admin on May 17, 2016 in |
The hypolipidemic activity of Aloe vera (Family: Liliaceae) extract has been studied in two models of hyperlipidemia in rats. In an acute model, hyperlipidemia was induced by injecting a single dose of triton WR-1339 (400mg/kg, b.w.) intraperitoneally in rats. Feeding with Aloe vera extract at the dose of 500 mg/ kg, b.w. exerted a significant lipid-lowering effect as assessed by the reversal of plasma levels of total cholesterol (TC), phospholipids (PL), triglyceride (TG) and reactivation of post-heparin lipolytic activity (PHLA). In the chronic model, hyperlipidemia was induced by feeding with cholesterol-rich- HFD in rats. The treatment with seeds extracts of Aloe vera (500 mg/ kg b.w) simultaneously for 15 days also caused lowering of lipid levels in plasma and liver following reactivation of plasma post-heparin lipolytic activity and hepatic lipoprotein lipase activity in animals. The hypolipidemic activity of Aloe vera was compared with a standard drug guggulipid (200 mg/ kg, b.w.) in both...
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Posted by admin on May 17, 2016 in |
The present investigation has been carried out to determine the antioxidant activity of the ethanolic extracts obtained from plant seeds belonging to family Leguminosae i.e., Lens culinaris, Vigna unguiculata, Dolichos biflorus and Phalaseous. Phenolic compounds present in the extracts showed the antioxidant and antiradical properties when investigated using a ferrous ion chelating ability and reducing power assay. The results indicated that ethanolic extracts of all four plant seeds resembled in the activities above. Phenolic constituents contained in plant mentioned above seeds may have a future role as ingredients in the development of functional...
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Posted by admin on May 17, 2016 in |
The study is aimed at the development of physicochemical parameters and to investigate the active principle present in Chlorophytum borvilianum and Sapindus mukorrossai. The present work embodies the investigations carried out to establish methods for quality control of drugs as per WHO guidelines: complete botanical evaluation which comprises of macroscopy, quantitative microscopy, powder microscopy, physicochemical parameters like loss on drying, extractive values, saponification value, total ash values, acid insoluble ash value, water-soluble ash value, pH value, loss on drying, bulk density and fluorescence analysis of powdered drug to investigate the phytochemicals present in the extracts in the preliminary...
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Posted by admin on May 17, 2016 in |
The aim of the present study, synthesis of new compounds of 4-methyl coumarin derivatives, from starting material (7-dihydroxy-4-methyl coumarin). A variety of chalcones derivative have been synthesized, and the proposed structures were confirmed by physical properties like UV –Visible, FT-IR and ¹ H NMR, Chem Bio Draw was used to evaluated the geometry optimization and total energies as well as dipole moment for all prepared...
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Posted by admin on Apr 23, 2016 in |
The present study was aimed to find out the antimicrobial potential of acetone extract of Acacia concinna leaf against five different bacterial strains at 100 and 200mg/ml concentrations. The disc diffusion assay was performed to access the antimicrobial potential of the extract. The agar plate containing a bacterial culture was divided into 4 zones, and each zone was independently impregnated with four sterile filter paper discs (6 mm in diameter) containing (10 µl of each concentration) distill water (Negative control), ampicillin (Positive control); Acacia concinna leaf extract (100 mg/ml and 200 mg/ml as test). Zone of inhibition and MIC (minimum inhibitory concentration) for test drug was evaluated to access the antimicrobial potency. The phytochemical analysis shows the presence of alkaloids, tannins, and glycosides that might be responsible for the aimed biological activities. Out of five bacterial strains, the test drug exhibit zone of inhibition against Mycobacterium smegmatis and Bacillus subtilis in a concentration-dependent manner. Minimum inhibitory concentration (MIC) of test drug against Mycobacterium smegmatis and Bacillus subtilis, was found...
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