PRILIMINARY PHYTOCHEMICAL SCREENING AND IN-VITRO ANTICONVULSANT ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF CINNAMOMUM TAMALA (BUCH.-HAM) T. NEES & EBERM (FAMILY- LAURACEAE)
AbstractObjective: To perform the phytochemical screening and anticonvulsant activity of methanolic extract of leaves of Cinnamomum tamala (Buch.-Ham) T. Nees & Eberm. Method: The physicochemical parameter and in-vitro anticonvulsant study were done. The anticonvulsant activity of methanolic extract of leaves of Cinnamomum tamala (100 and 400 mg/kg, p.o) in Wistar rats was assessed by using the Maximal Electric Shock test. Result: The present study shows different physicochemical analysis which reveals the presence of various metabolites. The methanolic extract of Cinnamomum tamala (Buch.-Ham) T. Nees & Eberm significantly reduced the duration of seizure induced by maximal electric shock. The methanolic extract of leaves of Cinnamomum tamala (Buch.-Ham) T. Nees & Eberm in doses of 100 and 400mg/kg conferred protection (39.65% and 45.97% respectively) on a rat. Conclusion: The methanolic extract of leaves of Cinnamomum tamala (Buch.-Ham) T. Nees & Eberm possess anticonvulsant activity since it reduced the duration of seizures produced by maximal electric shock.
Article Information
4
345-351
727
747
English
IJP
R. Phukan * and D. Shil
Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam, India.
rajdeepgips671@gmail.com
06 June 2017
22 August 2017
17 September 2017
10.13040/IJPSR.0975-8232.IJP.4(10).345-51
01 October 2017
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