Posted by admin on Jun 2, 2018 in |
The inhibitory effect of Juniperus phoenicea leaves extracts on Xanthine Oxidase activity was evaluated spectrophotometrically at 290 nm. Extracts of Juniperus phoenicea showed a potent XO inhibitory activity. To isolate the active compounds, an in-vitro bio-guided fractionation was undertaken by preparative chromatographic techniques. Fractions 2, 3 and 6 of ethyl acetate extract demonstrated substantial XO inhibitory activity (>80% inhibition) at 400 μg/mL. The highest inhibitory effect was obtained for fraction 3 (87.8%). The major constituents amentoflavone (1) and catechin (2) isolated from the fraction 3 were identified by extensive spectroscopic studies including 1D and 2D NMR experiments. These two compounds have no inhibitory effect on xanthine oxidase; it is deduced that the XOI activity of the fraction 3, was due either to a minor bioactive compound or possible synergisms. However, this study showed that the tested plant species are a potential source of natural XO inhibitors that can be developed, upon further investigation, for treatment of gout and other XO-related...
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Posted by admin on May 2, 2018 in |
The present research aimed at scrutinizing the role of Mahua Oil (MO) as a suppository base which can enhance the release of drug in the site of administration. Three formulations were designed with erythromycin as the drug utilizing; F1 (MO and Beeswax in the ratio of 3:1), F2 (MO and PEG 6000 in the ratio of 1:1), and F3 (cocoa butter – 100%) as the base material. The suppositories were prepared using pour molding method after suitable calibration of molds. All the formulations were characterized in terms of breaking strength, disintegration time, drug content, in-vitro dissolution, and accelerated stability studies. The MO containing formulations displayed a good breaking strength, optimized disintegration time, and higher drug content as compared to the cocoa butter formulation. The optimized formulation F2 represented the optimized release of 81.35% over the range of 1 h. A little difference in drug content (1.78%), breaking strength (0.2 Kg/cm2), and disintegrating time (0.6 min) was observed in the accelerated stability study. The study concluded that MO has a...
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Posted by admin on May 2, 2018 in |
Anatomical characters and thin layer chromatographic fingerprint of root, root-bark and leaf of Agnimanthaḥ (Premna serratifolia L.), an important drug used in Ayurvedic system of medicine has been studied in detail to identify the original drug from the...
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Posted by admin on May 2, 2018 in |
The drug is obtained from the dried fruit of Nyctanthes arbor-tristis of family Oleaceae. It is also called Coral Jasmine, Parijat, and Harsingar, etc. To confirm the veracity of the claim above, the anticonvulsant effect of the ethanolic extract has been evaluated. In this investigation, the rats were pretreated with different dose of Nyctanthes arbor-tristis ethanolic extract (100, 200 mg/kg) for 14th days and then, they were subjected to maximal electroshock-seizures, the dose of 100 and 200 mg/kg significantly reduced the duration of hind limb extension, and both the doses were statistically found to be equipotent. The reference, standard, Phenytoin (30 mg/kg) provided complete protection. Thus, the present study revealed the anticonvulsant effect of Nyctanthes arbor-tristis against maximal electroshock-induced convulsion in the...
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Posted by admin on May 2, 2018 in |
The present investigation was designed to prepare immediate release tablets of gliclazide with the ultimate aim of reducing the time needed to obtain the peak plasma concentration. Gliclazide immediate release tablets were prepared by using superdisintegrants namely- sodium starch glycolate and croscar-mellose sodium. The prepared tablets were evaluated for weight variation, hardness, friability, and dissolution. Data obtained from in-vitro dissolution tests were employed to zero order kinetic model. All the data were in the acceptable range. Compatibility study was conducted using Fourier transform infrared spectroscopy (FTIR). The drug and all the excipients showed good...
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